ArticleeLife2019
Human motor fatigability as evoked by repetitive movements results from a gradual breakdown of surround inhibition.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Spaced practice and reactive inhibition have limited or no effects on motor sequence learning.Scientific reports · 2026Article
- Finger tapping at maximal speed evokes crossover fatigability in the other hand.Frontiers in human neuroscience · 2026Article
- Changes in the cortical GABAergic inhibitory system with ageing and ageing-related neurodegenerative diseases.The Journal of physiology · 2026Review
- The effects of declarative learning on early and late motor skill learning.NPJ science of learning · 2025Article
- Micro-offline gains do not reflect offline learning during early motor skill acquisition in humans.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Overnight changes in performance fatigability and their relationship to modulated deep sleep oscillations via auditory stimulation.Journal of sleep research · 2025Article
- Focal mechanical vibration motor effects on the finger tapping in healthy volunteers.Frontiers in sports and active living · 2025Article
- Dynamic causal modelling highlights the importance of decreased self-inhibition of the sensorimotor cortex in motor fatigability.Brain structure & function · 2024Article
- Decoding visual fatigue in a visual search task selectively manipulated via myopia-correcting lenses.Frontiers in neuroscience · 2024Article
- Social environment-based opportunity costs dictate when people leave social interactions.Communications psychology · 2024Article
- Finger-specific effects of age on tapping speed and motor fatigability.Frontiers in human neuroscience · 2024Article
- Movement predictability modulates sensorimotor processing.Frontiers in human neuroscience · 2023Article
- Exploring the role of the left DLPFC in fatigue during unresisted rhythmic movements.Psychophysiology · 2022Article
- Choices favoring cognitive effort in a foraging environment decrease when multiple forms of effort and delay are interleaved.Cognitive, affective & behavioral neuroscience · 2022Article
- Inhibition for gain modulation in the motor system.Experimental brain research · 2022Review
- The effect of static stretching on key hits and subjective fatigue in eSports.Journal of physical therapy science · 2021Article
- Peripheral-central interplay for fatiguing unresisted repetitive movements: a study using muscle ischaemia and M1 neuromodulation.Scientific reports · 2021Article
- Fatigue following mild traumatic brain injury relates to visual processing and effort perception in the context of motor performance.NeuroImage. Clinical · 2021Article
- Interlimb Coordination Performance in Seated Position in Persons With Multiple Sclerosis: Reduced Amplitude Over 6 min and Higher Coordination Variability in Persons With Walking Fatigability.Frontiers in human neuroscience · 2021Article
- Anodal transcranial direct current stimulation reduces motor slowing in athletes and non-athletes.BMC neuroscience · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Motor fatigability emerges when demanding tasks are executed over an extended period of time. Here, we used repetitive low-force movements that cause a gradual reduction in movement speed (or 'motor slowing') to study the central component of fatigability in healthy adults. We show that motor slowing is associated with a gradual increase of net excitability in the motor network and, specifically, in primary motor cortex (M1), which results from overall disinhibition. Importantly, we link performance decrements to a breakdown of surround inhibition in M1, which is associated with high coactivation of antagonistic muscle groups. This is consistent with the model that a loss of inhibitory control might broaden the tuning of population vectors such that movement patterns become more variable, ill-timed and effortful. We propose that the release of inhibition in M1 is an important mechanism underpinning motor fatigability and, potentially, also pathological fatigue as frequently observed in patients with brain disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.