Evidence map›Paper›PMID 31523937›Full record

ReviewJournal of cachexia, sarcopenia and muscle2019

Sarcopenia: A Time for Action. An SCWD Position Paper.

Juergen Bauer, John E Morley, Annemie M W J Schols, Luigi Ferrucci, Alfonso J Cruz-Jentoft, Elsa Dent, Vickie E Baracos, Jeffrey A Crawford, Wolfram Doehner, Steven B Heymsfield and 12 more

Open access · goldAbstract readReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cachexia, sarcopenia and muscle, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 387 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
387citing papers in PubMed, 14 pooled it
40.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

387 citing papers in PubMed, 14 syntheses or guidelines pooled it, 709 citations in OpenAlex.

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  5. Effects of combined protein and exercise interventions on bone health in middle-aged and older adults - A systematic literature review and meta-analysis of randomized controlled trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
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  14. High-protein home parenteral nutrition in malnourished oncology patients: a systematic literature review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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327 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 19 institutions in 9 countries.

Juergen BauerCenter for Geriatric Medicine, Heidelberg University, Heidelberg, Germany.
John E MorleyDivision of Geriatric Medicine, Saint Louis University School of Medicine, St. Louis, USA.
Annemie M W J ScholsDepartment of Respiratory Medicine, Research School NUTRIM, Maastricht University Medical Center, Maastricht, The Netherlands.
Luigi FerrucciLongitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Alfonso J Cruz-JentoftServicio de Geriatría, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain.
Elsa DentTorrens University Australia, Adelaide, Australia.
Vickie E BaracosDivision of Palliative Care Medicine, Department of Oncology, University of Alberta, Edmonton, AB, Canada.
Jeffrey A CrawfordDuke Cancer Institute, Duke University, Durham, NC, USA.
Wolfram DoehnerBIH Center for Regenerative Therapies (BCRT), Charité Uinversitätsmedizin Berlin, Berlin, Germany.
Steven B HeymsfieldPennington Biomedical Research Center, LSU System, Baton Rouge, LA, USA.
Aminah JatoiDepartment of Oncology, Mayo Clinic, Rochester, MN, USA.
Kamyar Kalantar-ZadehDivision of Nephrology and Hypertension, University of California Irvine Medical Center, Orange, CA, USA.
Mitja LainscakDivision of Cardiology, General Hospital Murska Sobota, Murska Sobota, Slovenia.
Francesco LandiInstitute of Internal Medicine and Geriatrics, Università Cattolica del Sacro Cuore, Rome, Italy.
Alessandro LavianoDepartment of Translational and Precision Medicine, Sapienza University, Rome, Italy.
Michelangelo MancusoDepartment of Clinical and Experimental Medicine, Neurological Institute, University of Pisa, Pisa, Italy.
Maurizio MuscaritoliDepartment of Translational and Precision Medicine, Sapienza University, Rome, Italy.
Carla M PradoHuman Nutrition Research Unit, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada.
Florian StrasserDepartment of Medical Oncology and Hematology, Cantonal Hospital, St. Gallen, Switzerland.
Stephan von HaehlingDepartment of Cardiology and Pneumology, University Medicine Goettingen (UMG), Goettingen, Germany.
Andrew J S CoatsDepartment of Cardiology, IRCCS San Raffaele Pisana, Rome, Italy.
Stefan D AnkerBIH Center for Regenerative Therapies (BCRT), Charité Uinversitätsmedizin Berlin, Berlin, Germany.
Berlin-Brandenburger Centrum für Regenerative Therapien · DESapienza University of Rome · ITUniversity of Alberta · CABaker Heart and Diabetes Institute · AUDuke University · USHeidelberg University · DEInstituto Ramón y Cajal de Investigación Sanitaria · ESIRCCS Ospedale San Raffaele · ITMaastricht University Medical Centre · NLMayo Clinic in Arizona · USNational Institutes of Health · USNephrologisches Zentrum Goettingen · DEPennington Biomedical Research Center · USPomurski muzej Murska Sobota · SISaint Louis University · USUniversità Cattolica del Sacro Cuore · ITUniversity of California, Irvine Medical Center · USUniversity of Pisa · ITUniversity of St.Gallen · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The term sarcopenia was introduced in 1988. The original definition was a "muscle loss" of the appendicular muscle mass in the older people as measured by dual energy x-ray absorptiometry (DXA). In 2010, the definition was altered to be low muscle mass together with low muscle function and this was agreed upon as reported in a number of consensus papers. The Society of Sarcopenia, Cachexia and Wasting Disorders supports the recommendations of more recent consensus conferences, i.e. that rapid screening, such as with the SARC-F questionnaire, should be utilized with a formal diagnosis being made by measuring grip strength or chair stand together with DXA estimation of appendicular muscle mass (indexed for height2). Assessments of the utility of ultrasound and creatine dilution techniques are ongoing. Use of ultrasound may not be easily reproducible. Primary sarcopenia is aging associated (mediated) loss of muscle mass. Secondary sarcopenia (or disease-related sarcopenia) has predominantly focused on loss of muscle mass without the emphasis on muscle function. Diseases that can cause muscle wasting (i.e. secondary sarcopenia) include malignant cancer, COPD, heart failure, and renal failure and others. Management of sarcopenia should consist of resistance exercise in combination with a protein intake of 1 to 1.5 g/kg/day. There is insufficient evidence that vitamin D and anabolic steroids are beneficial. These recommendations apply to both primary (age-related) sarcopenia and secondary (disease related) sarcopenia. Secondary sarcopenia also needs appropriate treatment of the underlying disease. It is important that primary care health professionals become aware of and make the diagnosis of age-related and disease-related sarcopenia. It is important to address the risk factors for sarcopenia, particularly low physical activity and sedentary behavior in the general population, using a life-long approach. There is a need for more clinical research into the appropriate measurement for muscle mass and the management of sarcopenia. Accordingly, this position statement provides recommendations on the management of sarcopenia and how to progress the knowledge and recognition of sarcopenia.

Indexed as

Disease ManagementDisease SusceptibilityHumansPractice Guidelines as TopicSarcopeniaCachexiaGeriatric assessmentMuscleMuscle strengthSarcopeniaSkeletal

Identifiers

PMID31523937
PMCPMC6818450
OpenAlexW2974171230

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.