ArticleEMBO reports2019
The ubiquitin E2 enzyme UBE2QL1 mediates lysophagy.
Article in EMBO reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Selective autophagy of intracellular organelles: recent research advances.Theranostics · 2021Pooled it
- Lysosomal homeostasis at the crossroads of neurodegeneration.The Journal of clinical investigation · 2026Review
- From homeostasis to pathology, organelle-specific autophagy in skeletal muscle: a PRISMA-ScR scoping review.Frontiers in physiology · 2026Review
- Niemann-Pick Disease Type C (NPDC) by Mutation ofAntioxidants (Basel, Switzerland) · 2023Review
- Targeting lysosomes in human disease: from basic research to clinical applications.Signal transduction and targeted therapy · 2021Review
- Lysosome Depletion-Triggered Autophagy Impairment in Progressive Kidney Injury.Kidney diseases (Basel, Switzerland) · 2021Review
- Autophagy in Acute Pancreatitis: Organelle Interaction and microRNA Regulation.Oxidative medicine and cellular longevity · 2021Review
- Autophagy-Dependent Ferroptosis: Machinery and Regulation.Cell chemical biology · 2020Review
- The ubiquitin E2 enzyme UBE2QL1 mediates lysophagy.EMBO reports · 2019Article
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Abstract
Although damaged lysosomes with ruptured membranes can be repaired, these dangerous organelles are also selectively eliminated by autophagic degradation termed lysophagy. This process is initiated by ubiquitination of lysosomal proteins. In this issue of EMBO Reports, Koerver et al [1] identify the E2 enzyme UBE2QL1 that catalyzes ubiquitination of damaged lysosomes. Without this enzyme, the clearance of ruptured lysosomes is compromised not only upon lysosomal damage but also under normal conditions, revealing its adaptive and constitutive functions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.