Evidence map›Paper›PMID 31523866›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2019

Synthesis of 5-Alkyl- and 5-Phenylamino-Substituted Azothiazole Dyes with Solvatochromic and DNA-Binding Properties.

Phil M Pithan, Christopher Kuhlmann, Carsten Engelhard, Heiko Ihmels

Open access · hybridAbstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Phil M PithanDepartment of Chemistry and Biology, and Center of Micro- and Nanochemistry and Engineering, University of Siegen, Adolf-Reichwein-Str. 2, 57068, Siegen, Germany.ORCID http://orcid.org/0000-0002-0997-3613
Christopher KuhlmannDepartment of Chemistry and Biology, and Center of Micro- and Nanochemistry and Engineering, University of Siegen, Adolf-Reichwein-Str. 2, 57068, Siegen, Germany.ORCID http://orcid.org/0000-0003-2856-9971
Carsten EngelhardDepartment of Chemistry and Biology, and Center of Micro- and Nanochemistry and Engineering, University of Siegen, Adolf-Reichwein-Str. 2, 57068, Siegen, Germany.ORCID http://orcid.org/0000-0002-7020-9278
Heiko IhmelsDepartment of Chemistry and Biology, and Center of Micro- and Nanochemistry and Engineering, University of Siegen, Adolf-Reichwein-Str. 2, 57068, Siegen, Germany.ORCID http://orcid.org/0000-0003-0969-0426
University of Siegen · DE

Funding

Deutsche Forschungsgemeinschaft INST 221/116-1 FUGGFCI - Fonds der Chemischen Industrie Liebig FellowshipFundación Cardioinfantil - Instituto de Cardiología Liebig Fellowship
6 · The paper itself

Abstract

A series of new 5-mono- and 5,5'-bisamino-substituted azothiazole derivatives was synthesized from the readily available diethyl azothiazole-4,4'-dicarboxylate. This reaction most likely comprises an initial Michael-type addition by the respective primary alkyl and aromatic amines at the carbon atom C5 of the substrate. Subsequently, the resulting intermediates are readily oxidized by molecular oxygen to afford the amino-substituted azothiazole derivatives. The latter exhibit remarkably red-shifted absorption bands (λ

Indexed as

azothiazole dyesDNA ligandsfluorescent probesintercalationsolvatochromism

Identifiers

PMID31523866
PMCPMC6973281
OpenAlexW2973309254

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.