Evidence map›Paper›PMID 31523792›Full record

ArticleDiving and hyperbaric medicine2019

Only minor stem cell mobilization in head and neck irradiated patients treated with hyperbaric oxygen.

Lone Forner, Adela Berkowicz, Ebbe Dickmeiss, Ole Hyldegaard, Erik C Jansen, Anne Fischer-Nielsen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diving and hyperbaric medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lone FornerCorresponding author: Dr Lone Forner, Department of Oral and Maxillofacial Surgery, Centre for Head and Orthopedics and Department of Anaesthesia, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark, lone.forner@regionh.dk.
Adela BerkowiczCell Therapy Facility, Department of Clinical Immunology, Centre of Diagnostic Investigation, Copenhagen University Hospital, Copenhagen, Denmark.
Ebbe DickmeissCell Therapy Facility, Department of Clinical Immunology, Centre of Diagnostic Investigation, Copenhagen University Hospital, Copenhagen, Denmark.
Ole HyldegaardDepartment of Anaesthesia, Centre for Head and Orthopedics, Copenhagen University Hospital, Copenhagen, Denmark.
Erik C JansenDepartment of Anaesthesia, Centre for Head and Orthopedics, Copenhagen University Hospital, Copenhagen, Denmark.
Anne Fischer-NielsenCell Therapy Facility, Department of Clinical Immunology, Centre of Diagnostic Investigation, Copenhagen University Hospital, Copenhagen, Denmark.
Copenhagen University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHyperbaric oxygen, (HBO) is used to treat several conditions including late radiation tissue injury. Previous studies have suggested that HBO mobilizes bone marrow derived stem/progenitor cells (SPC) to the peripheral blood, however possible cumulative effects were highly variable.

methodsWe have investigated a possible HBO-induced mobilization of SPCs by determining CD34+CD45dim cell numbers, as well as SPCs in general. The latter were characterized by high aldehyde dehydrogenase (ALDH) activity by use of the Aldefluor® assay. We included ten patients admitted for HBO treatment of radiation tissue injury. Six patients completed the 29-30 HBO treatment exposures. We also investigated possible HBO-induced effects on platelet activation as measured by flow cytometry and functional analyses.

resultsWe found a weak and insignificant tendency toward mobilization of CD34+CD45dim cells after a single HBO exposure versus before. Additionally, we found an additive effect of 15 HBO exposures on the increase in CD34+CD45dim cells relative to the pre-1st-HBO values. These changes were significantly more than zero but less than a doubling. We could not demonstrate a significant effect of HBO on the content of Aldefluor® positive SPCs in peripheral blood. There was no significant effect on platelet activation overall. However, in patients with increased expression of activation markers at baseline, we found a decrease after one exposure although this was not reflected in functional tests.

conclusionWe found a minor statistically significant mobilizing effect of HBO treatment on the bone marrow derived stem/progenitor cell content in peripheral blood after 15 treatments (n = 10 patients), but no effect after 30 treatments (n = 6 patients). However, because of the low number of patients we cannot confidentially prove or disprove the null hypothesis. The possibility that HBO treatment reduces the number of activated platelets could not be demonstrated nor excluded.

Indexed as

Hematopoietic Stem Cell MobilizationHyperbaric OxygenationRadiation InjuriesHumansOxygenRadiotherapyOxygenHead and neck cancerHyperbaric oxygenOsteoradionecrosisPlateletsSoft-tissue radionecrosisStem cells

Identifiers

PMID31523792
PMCPMC6884100
OpenAlexW2972789177

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.