ArticleClinical rheumatology2020
Rheumatoid arthritis and neurodegenerative dementia: a nested case-control study and a follow-up study using a national sample cohort.
Article in Clinical rheumatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Population attributable fractions of a wide range of peripheral diseases for the burden of dementia.Nature human behaviour · 2026Pooled it
- The association between systemic lupus erythematosus and cognitive impairment or dementia: a meta-analysis.Frontiers in immunology · 2026Pooled it
- Association between systemic rheumatic diseases and dementia risk: A meta-analysis.Frontiers in immunology · 2022Pooled it
- Temporal incidence and impact of dementia in rheumatoid arthritis: a cohort study.EULAR rheumatology open · 2026Article
- Spatio-temporal patterns of neurodegenerative disease hospitalizations in mainland Portugal.Frontiers in public health · 2026Article
- Association of Rheumatoid Arthritis With Progression of Cognitive Impairment and Risk of Mortality in People With Dementia.Neurology · 2025Article
- Article
- Cognitive impairment in individuals with rheumatic diseases: the role of systemic inflammation, immunomodulatory medications, and comorbidities.The Lancet. Rheumatology · 2024Review
- The impact of cardiovascular and cerebrovascular disease on the risk of dementia in rheumatoid arthritis: A mediation analysis.Seminars in arthritis and rheumatism · 2024Article
- Validation of Different Dementia Code-Based Definitions in a Population-Based Study of Rheumatoid Arthritis.The Journal of rheumatology · 2024Article
- Causality between rheumatoid arthritis and the risk of cognitive impairment: a Mendelian randomization study.Arthritis research & therapy · 2024Article
- Association between Gallstone Disease and Statin Use: A Nested Case-Control Study in Korea.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Risk Factors for Dementia in Patients With Incident Rheumatoid Arthritis: A Population-Based Cohort Study.The Journal of rheumatology · 2023Article
- Association between Migraines and Prior Proton Pump Inhibitor Use: A Nested Case-Control Study Using a National Health Screening Cohort.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Possible Association between the Use of Proton Pump Inhibitors and HPharmaceuticals (Basel, Switzerland) · 2022Article
- Rheumatoid Arthritis, Cognitive Impairment, and Neuroimaging Biomarkers: Results from the Mayo Clinic Study of Aging.Journal of Alzheimer's disease : JAD · 2022Article
- No increased risk of Alzheimer's disease among people with immune-mediated inflammatory diseases: findings from a longitudinal cohort study of U.S. older adults.BMC rheumatology · 2021Article
- No association between rheumatoid arthritis and cognitive impairment in a cross-sectional national sample of older U.S. adults.BMC rheumatology · 2021Article
- Trends in incidence of dementia among patients with rheumatoid arthritis: A population-based cohort study.Seminars in arthritis and rheumatism · 2021Article
- Gender- and age-related differences of statin use on incident dementia in patients with rheumatoid arthritis: a Nationwide population-based cohort study.Lipids in health and disease · 2021Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
objectivesThe present study evaluated the associations between rheumatoid arthritis (RA) and neurodegenerative dementia using a Korean national sample cohort.
methodsWe designed two studies using the Korean National Health Insurance Service-National Sample Cohort from 2002 to 2013. Study I included participants with dementia matched 1:4 with controls and analyzed the participants' history of RA. Study II included participants with RA matched 1:4 with controls and analyzed the occurrence of dementia. RA was defined by the presence of relevant ICD-10 codes (M05 or M06) and medication histories. Neurodegenerative dementia was defined using ICD-10 codes (G30 or F00). Crude and adjusted odds ratios (ORs) were analyzed using conditional logistic regression analyses. Crude and adjusted hazard ratios (HRs) were analyzed using the stratified Cox proportional hazard model. Subgroup analyses were performed on groups stratified by age and sex.
resultsThe adjusted ORs for RA were 0.96 (95% CI = 0.78-1.16, P = 0.644) in the dementia group in study I. The adjusted HRs for dementia were 0.91 (95% CI = 0.76-1.10, P = 0.319) in the RA group in study II. No subgroup analysis reached the statistical significance level.
conclusionWe could not identify any significant relationship between RA and dementia.Key Points• Two studies were conducted to identify the relationship between rheumatoid arthritis and dementia using national cohort data.• Neither study showed any association between rheumatoid arthritis and dementia.
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