Evidence map›Paper›PMID 31523757›Full record

SynthesisNeuroradiology2019

Diagnostic accuracy of flat-panel computed tomography in assessing cerebral perfusion in comparison with perfusion computed tomography and perfusion magnetic resonance: a systematic review.

Ernst L Stille, Ilaria Viozzi, Mark Ter Laan, Frederick J A Meijer, Jurgen J Futterer, Maroeska M Rovers

Open access · hybridAbstract readSystematic Review
In one paragraph

Synthesis in Neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ernst L StilleDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 10, 766, PO Box 9101, 6500HB, Nijmegen, The Netherlands. tip.stille@radboudumc.nl.ORCID http://orcid.org/0000-0002-2655-3493
Ilaria ViozziDepartment of Neurosurgery, Radboud University Medical Center, Geert Grooteplein Zuid 10, 725, 6525GA, Nijmegen, The Netherlands.
Mark Ter LaanDepartment of Neurosurgery, Radboud University Medical Center, Geert Grooteplein Zuid 10, 725, 6525GA, Nijmegen, The Netherlands.
Frederick J A MeijerDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 10, 766, PO Box 9101, 6500HB, Nijmegen, The Netherlands.
Jurgen J FuttererDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 10, 766, PO Box 9101, 6500HB, Nijmegen, The Netherlands.
Maroeska M RoversDepartment of Operating Rooms, Radboud University Medical Center, Geert Grooteplein Zuid 10, 715, 6525GA, Nijmegen, The Netherlands.
Radboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFlat-panel computed tomography (FP-CT) is increasingly available in angiographic rooms and hybrid OR's. Considering its easy access, cerebral imaging using FP-CT is an appealing modality for intra-procedural applications. The purpose of this systematic review is to assess the diagnostic accuracy of FP-CT compared with perfusion computed tomography (CTP) and perfusion magnetic resonance (MRP) in cerebral perfusion imaging.

methodsWe performed a systematic literature search in the Cochrane Library, MEDLINE, Embase, and Web of Science up to June 2019 for studies directly comparing FP-CT with either CTP or MRP in vivo. Methodological quality was assessed using the QUADAS-2 tool. Data on diagnostic accuracy was extracted and pooled if possible.

resultsWe found 11 studies comparing FP-CT with CTP and 5 studies comparing FP-CT with MRP. Most articles were pilot or feasibility studies, focusing on scanning and contrast protocols. All patients studied showed signs of cerebrovascular disease. Half of the studies were animal trials. Quality assessment showed unclear to high risks of bias and low concerns regarding applicability. Five studies reported on diagnostic accuracy; FP-CT shows good sensitivity (range 0.84-1.00) and moderate specificity (range 0.63-0.88) in detecting cerebral blood volume (CBV) lesions.

conclusionsEven though FP-CT provides similar CBV values and reconstructed blood volume maps as CTP in cerebrovascular disease, additional studies are required in order to reliably compare its diagnostic accuracy with cerebral perfusion imaging.

Indexed as

Cerebrovascular CirculationCerebral AngiographyCerebrovascular DisordersHumansMagnetic Resonance AngiographySensitivity and SpecificityTomography, X-Ray ComputedCerebral perfusion imagingFlat-panel detector computed tomographyPerfusion computed tomographyPerfusion magnetic resonance

Identifiers

PMID31523757
PMCPMC6848034
OpenAlexW2974735599

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.