Evidence map›Paper›PMID 31523620›Full record

ArticleBalkan journal of medical genetics : BJMG2019

Comparative Expression Analysis of Human Endogenous Retrovirus Elements in Peripheral Blood of Children with Specific Language Impairment.

D S Minchev, N T Popov, S I Naimov, I N Minkov, T I Vachev

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Balkan journal of medical genetics : BJMG, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

D S MinchevDepartment of Plant Physiology and Molecular Biology, University of Plovdiv "Paisii Hilendarski," Plovdiv, Bulgaria.
N T PopovPsychiatric Ward for Active Treatment of Men, State Phsychiatry Hospital Pazardzhik, Pazardzhik, Bulgaria.
S I NaimovDepartment of Plant Physiology and Molecular Biology, University of Plovdiv "Paisii Hilendarski," Plovdiv, Bulgaria.
I N MinkovInstitute of Molecular Biology and Biotechnologies (IMBB), Plovdiv, Bulgaria.
T I VachevDepartment of Plant Physiology and Molecular Biology, University of Plovdiv "Paisii Hilendarski," Plovdiv, Bulgaria.
Plovdiv University · BGInstitute of Molecular Biology and Biotechnology · BGMedical University Plovdiv · BG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Specific language impairment (SLI) is a psychiatric condition with a complex etiology and a substantial genetic basis that affects children's verbal communication abilities. In this study, we examined the expression of five different human endogenous retrovirus elements (HERVs) in a cohort of 25 children with SLI and 25 healthy children in the control group. Human endogenous retrovirus elements, a diverse group of repetitive DNA sequences, can potentially cause considerable genetic heterogeneity. They had been integrated in the genome of our ancestors throughout evolution and now consist of about 8.0% of the human genome. Several HERV loci are transcribed in various cell types. Their expression in peripheral blood and in the brain is altered in many neurological and psychiatric diseases. To date, HERV expression profiles have never been studied in patients with SLI. This study aimed to elucidate differentially regulated human endogenous retroelements in peripheral blood of children with SLI, in comparison with healthy controls, through quantitative reverse tran-scription-polymerase chain reaction (qRT-PCR) methodology. Our results show that two genes: HERV-K (HLM-2)

Indexed as

Blood-based quantitative reverse transcription-polymerase chain reaction (qRT-PCR)expression profilingHuman endogenous retrovirus elements (HERV)Relative quantitationSpecific language impairment (SLI)

Identifiers

PMID31523620
PMCPMC6714331
OpenAlexW2970483731

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.