ArticleInternational journal of biological sciences2019
Microtubule-associated protein 4 phosphorylation regulates epidermal keratinocyte migration and proliferation.
Article in International journal of biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Autophagy and mitophagy in dermatological disease: a comprehensive review from molecular pathways to therapeutic frontiers.Biology direct · 2025Review
- Review
- Wound healing and signaling pathways.Open life sciences · 2025Review
- Matrix Metalloproteinases on Skin Photoaging.Journal of cosmetic dermatology · 2024Review
- Potential Wound Healing and Anti-Melanogenic Activities in Skin Cells ofPharmaceutics · 2024Article
- MAP4 acts as an oncogene and prognostic marker and affects radioresistance by mediating epithelial-mesenchymal transition in lung adenocarcinoma.Journal of cancer research and clinical oncology · 2024Article
- Article
- CHKB-AS1 enhances proliferation and resistance to NVP-BEZ235 of renal cancer cells via regulating the phosphorylation of MAP4 and PI3K/AKT/mTOR signaling.European journal of medical research · 2023Article
- Mitophagy associated self-degradation of phosphorylated MAP4 guarantees the migration and proliferation responses of keratinocytes to hypoxia.Cell death discovery · 2023Article
- Skin Wound Healing and Anti-Wrinkle-Promoting In Vitro Biological Activities ofPharmaceuticals (Basel, Switzerland) · 2023Article
- [Effect of P62 on the migration and motility of human epidermal cell line HaCaT in high glucose microenvironment and its mechanism].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Article
- Chemical Composition ofPharmaceuticals (Basel, Switzerland) · 2022Article
- Mechanical Stretch Induced Skin Regeneration: Molecular and Cellular Mechanism in Skin Soft Tissue Expansion.International journal of molecular sciences · 2022Review
- The abnormal phosphorylation of the Rac1, Lim-kinase 1, and Cofilin proteins in the pathogenesis of Hirschsprung's disease.Bioengineered · 2022Article
- Chemical Composition ofPlants (Basel, Switzerland) · 2022Article
- The establishment and development of wound repair discipline in China.Frontiers in surgery · 2022Review
- Wound Healing-Promoting and Melanogenesis-Inhibiting Activities ofMolecules (Basel, Switzerland) · 2021Article
- Resveratrol promotes skin wound healing by regulating the miR-212/CASP8 axis.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- [Effects and molecular mechanism of histone deacetylase 6 inhibitor Tubastatin A on the prolifera- tion and movement of human skin fibroblasts].Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns · 2021Article
- SETD2 epidermal deficiency promotes cutaneous wound healing via activation of AKT/mTOR Signalling.Cell proliferation · 2021Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both cell migration and proliferation are indispensable parts of reepithelialization during skin wound healing, which is a complex process for which the underlying molecular mechanisms are largely unknown. Here, we identify a novel role for microtubule-associated protein 4 (MAP4), a cytosolic microtubule-binding protein that regulates microtubule dynamics through phosphorylation modification, as a critical regulator of epidermal wound repair. We showed that MAP4 phosphorylation was induced in skin wounds. In an aberrant phosphorylated MAP4 mouse model, hyperphosphorylation of MAP4 (S737 and S760) accelerated keratinocyte migration and proliferation and skin wound healing. Data from both primary cultured keratinocytes and HaCaT cells
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.