ArticleInternational journal of trichology
Histopathology of Hair Follicle Epithelium in Patients of Recurrent and Recalcitrant Dermatophytosis: A Diagnostic Cross-Sectional Study.
Article in International journal of trichology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 11 citations in OpenAlex.
- Histology-Correlated FTIR Chemical Imaging of Fungal Infection-Associated Tissue Compartments in Human Skin: A Proof-of-Concept Study.Diagnostics (Basel, Switzerland) · 2026Article
- A case of dermatophyte abscess and adjunctive use of a novel RNA: In situ hybridization to confirmJAAD case reports · 2024Article
- A Clinico-Mycological and Histopathological Study of Recurrent Dermatophytosis.Indian dermatology online journalArticle
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4 authors at 1 institution in 1 country.
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Abstract
contextRecurrent and recalcitrant dermatophytosis is a major evolving health problem in India. Histopathology is important in the diagnosis of recurrent and resistant cases, as it is postulated that hair follicle epithelium is affected, acting as the reservoir leading to recurrence and recalcitrance.
aimsThis study aims to study histopathology of hair follicle epithelium in patients of recurrent and recalcitrant dermatophytosis. SETTINGS AND
designA diagnostic cross-sectional study was performed at tertiary care hospital and referral center in central India. MATERIALS AND
methodsA 3 mm-sized punch skin biopsy was taken from 108 patients of recurrent or recalcitrant dermatophytosis involving hair follicles. Sections were stained by hematoxylin and eosin (H and E) stain in these patients followed by special stains such as periodic acid-Schiff (PAS) stain and Gomori methenamine silver (GMS) stain in 78 individuals where hair follicle was seen on H and E stain.
resultsIn H and E stain, surface epidermis fungus was observed in 57/108 patients (52.7%). In hair follicle-positive sections (78), surface fungus was seen in 52.6% with H and E stain, 84.6% with PAS stain, and 91% with GMS stain. H and E was 62.12% sensitive and 100% specific to diagnose fungus when compared with PAS stain and 57.7% sensitive and 100% specific when compared with GMS stain. PAS was 91.5% sensitive and 85.7% specific when compared with GMS stain. Ectothrix infection was the most common form of hair infection observed in 87.2% cases with GMS stain. Simultaneous presence of fungus in hair follicle and stratum corneum was observed in 87.3% of patients.
conclusionMajority of patients showed affection of hair follicles by dermatophytes in clinically chronic, recurrent, and recalcitrant dermatophytic infections. GMS stain is the acceptable gold standard for detection of fungal elements.
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