ArticleStem cell reports2019
PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia.
Registry-linked trialOpen access · goldAbstract read
In one paragraph
Article in Stem cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05522387 (An Open Label Extension of XPro1595 in Patients With Alzheimer's Disease That Have Completed a Phase 1 or Phase 2 Study With XPro1595), which is not on this map. Cited by 118 papers.
0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Open Label Extension of XPro1595 in Patients With Alzheimer's Disease That Have Completed a Phase 1 or Phase 2 Study With XPro1595
Who cites it
118 citing papers in PubMed, 202 citations in OpenAlex.
- Human iPSC models revealResearch square · 2026Article
- C9orf72-associated and sporadic FTD patient iPSC-microglia show differences in phagocytosis and gene expression.Stem cell reports · 2026Article
- Cross-tissue immune profiling of APOE ε4 reveals early dysregulation in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Human Stem Cell-Derived Models of the Alzheimer's Disease Neuroimmune System.International journal of molecular sciences · 2026Review
- Alteration in oral and non-oral tissues in ligature-induced periodontitis mice with the Alzheimer's disease risk factor APOE4.European journal of oral sciences · 2026Article
- KOLF2.1J iTF-Microglia: A standardized platform to study microglial transcriptional regulatory networks in CNS disease.iScience · 2026Article
- TNF-α induces type I IFN signalling to suppress neurogenesis and recruit T cells.Nature communications · 2026Article
- Article
- Alzheimer's Disease Risk AllelebioRxiv : the preprint server for biology · 2026Article
- Dissecting microglial contributions to neurodegenerative disease pathophysiology using human pluripotent stem cells.Stem cell reports · 2026Review
- microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer's disease patients.Acta neuropathologica communications · 2026Article
- Apolipoprotein E Deficiency Impairs Human Microglial Proliferation Accompanied by Elevated Cellular Oxidative Stress.Journal of cellular and molecular medicine · 2026Article
- Modeling neurovascular dysfunction in Alzheimer's disease using an isogenic brain-chip model.Fluids and barriers of the CNS · 2026Article
- From metabolism to neurodegeneration: how microglial functional reprogramming drives neurodegenerative diseases.Frontiers in molecular neuroscience · 2026Review
- APPswe mutation causes functional deficits in endothelial cells generated by transient ETV2 overexpression in human iPSCs.Fluids and barriers of the CNS · 2025Article
- Microglia from patients with multiple sclerosis display a cell-autonomous immune activation state.Journal of neuroinflammation · 2025Article
- Review
- Microglial Drivers of Alzheimer's Disease Pathology: An Evolution of Diverse Participating States.Proteins · 2025Review
- Modeling neuroinflammatory interactions between microglia and astrocytes in a human iPSC-based coculture platform.Cell communication and signaling : CCS · 2025Article
- Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype.Journal of neuroinflammation · 2025Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors at 9 institutions in 5 countries.
Henna KonttinenA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio 70211, Finland.
Mauricio E Castro Cabral-da-SilvaSchool of Chemistry and Molecular Bioscience, Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia.
Sohvi OhtonenA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio 70211, Finland.
Sara WojciechowskiA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio 70211, Finland.
Anastasia ShakirzyanovaA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio 70211, Finland.
Simone CaligolaDepartment of Computer Science, University of Verona, Verona 37134, Italy.
Rosalba GiugnoDepartment of Computer Science, University of Verona, Verona 37134, Italy.
Yevheniia IshchenkoA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio 70211, Finland.
Damián HernándezCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, VIC 3002, Australia; Department of Surgery, the University of Melbourne, Melbourne, VIC 3002, Australia; Department of Anatomy and Neuroscience, the University of Melbourne, Melbourne, VIC 3002, Australia.
Mohammad Feroze FazaludeenA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio 70211, Finland.
Shaila EamenA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio 70211, Finland.
Mireia Gómez BudiaA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio 70211, Finland.
Ilkka FagerlundA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio 70211, Finland.
Flavia ScoyniA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio 70211, Finland.
Paula KorhonenA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio 70211, Finland.
Nadine HuberA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio 70211, Finland.
Annakaisa HaapasaloA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio 70211, Finland.
Alex W HewittCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, VIC 3002, Australia; Department of Surgery, the University of Melbourne, Melbourne, VIC 3002, Australia; School of Medicine, Menzies Institute for Medical Research, University of Tasmania, Hobart, VIC 7005, Australia.
James VickersWicking Dementia Research and Education Centre, University of Tasmania, Hobart, TAS 7000, Australia.
Grady C SmithSchool of Chemistry and Molecular Bioscience, Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia.
Minna OksanenA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio 70211, Finland.
Caroline GraffDepartment NVS, Division of Neurogeriatrics, Karolinka Institutet, Stockholm 17176, Sweden; Theme Aging, Genetics Unit, Karolinska University Hospital-Solna, Stockholm 17176, Sweden.
Katja M KanninenA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio 70211, Finland.
Sarka LehtonenA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio 70211, Finland.
Nicholas PropsonDepartment of Molecular and Cell Biology and the Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
Michael P SchwartzDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Alice PébayCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, VIC 3002, Australia; Department of Surgery, the University of Melbourne, Melbourne, VIC 3002, Australia; Department of Anatomy and Neuroscience, the University of Melbourne, Melbourne, VIC 3002, Australia.
Jari KoistinahoA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio 70211, Finland; Neuroscience Center, University of Helsinki, Helsinki 00014, Finland.
Lezanne OoiSchool of Chemistry and Molecular Bioscience, Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia.
Tarja MalmA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio 70211, Finland. Electronic address: tarja.malm@uef.fi.
University of Eastern Finland · FIUniversity of Wollongong · AUThe University of Melbourne · AUUniversity of Tasmania · AUUniversity of Verona · ITBaylor College of Medicine · USKarolinska University Hospital · SEUniversity of Helsinki · FIUniversity of Wisconsin–Madison · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here we elucidate the effect of Alzheimer disease (AD)-predisposing genetic backgrounds, APOE4, PSEN1ΔE9, and APPswe, on functionality of human microglia-like cells (iMGLs). We present a physiologically relevant high-yield protocol for producing iMGLs from induced pluripotent stem cells. Differentiation is directed with small molecules through primitive erythromyeloid progenitors to re-create microglial ontogeny from yolk sac. The iMGLs express microglial signature genes and respond to ADP with intracellular Ca
Indexed as
PhenotypeAlzheimer DiseaseAmyloid beta-Protein PrecursorApolipoprotein E4CalciumCell DifferentiationCells, CulturedChemokinesCytokinesHematopoiesisHumansInduced Pluripotent Stem CellsInflammation MediatorsMicrogliaMutationPhagocytosisAmyloid beta-Protein PrecursorApolipoprotein E4APP protein, humanCalciumChemokinesCytokinesInflammation MediatorsPresenilin-1PSEN1 protein, humanAlzheimer diseaseAPOEAPPsweE9iPSCmetabolismmicrogliamitochondriaphagocytosisPSEN1Δ
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
NCT05522387ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.