Evidence map›Paper›PMID 31522867›Full record

ArticleSchizophrenia research2020

An imaging-based risk calculator for prediction of conversion to psychosis in clinical high-risk individuals using glutamate

Lawrence S Kegeles, Adam Ciarleglio, Pablo León-Ortiz, Francisco Reyes-Madrigal, Jeffrey A Lieberman, Gary Brucato, Ragy R Girgis, Camilo de la Fuente-Sandoval

Open access · greenAbstract read
In one paragraph

Article in Schizophrenia research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Empirical validation of race-neutral normative brain morphometry models across ethnoracially diverse populations.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Observational
  4. Article
  5. Candidate biomarkers in psychiatric disorders: state of the field.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023
    Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Lawrence S KegelesColumbia University, Department of Psychiatry, New York State Psychiatric Institute (NYSPI), New York, NY, USA.
Adam CiarleglioGeorge Washington University, Milken Institute School of Public Health, Department of Epidemiology and Biostatistics, Washington, DC, USA.
Pablo León-OrtizLaboratory of Experimental Psychiatry, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico.
Francisco Reyes-MadrigalLaboratory of Experimental Psychiatry, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico.
Jeffrey A LiebermanColumbia University, Department of Psychiatry, New York State Psychiatric Institute (NYSPI), New York, NY, USA.
Gary BrucatoColumbia University, Department of Psychiatry, New York State Psychiatric Institute (NYSPI), New York, NY, USA.
Ragy R GirgisColumbia University, Department of Psychiatry, New York State Psychiatric Institute (NYSPI), New York, NY, USA.
Camilo de la Fuente-SandovalLaboratory of Experimental Psychiatry, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico. Electronic address: fcamilo@unam.mx.
New York Psychoanalytic Society and Institute · USInstituto Nacional de Neurología y Neurocirugía · MXMilken Institute · US

Funding

Biomarkers of Conversion Risk and Treatment Response in Early-Stage SchizophreniaR01MH110270 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI GIRGIS, RAGY RAMSIS, KEGELES, LAWRENCE S · 2017 to 2021
$3.7M
NIMH NIH HHS R01 MH110270
6 · The paper itself

Abstract

Risk calculators for prediction of conversion of Clinical High-Risk (CHR) individuals to syndromal psychosis have recently been developed and have generated considerable clinical use and research interest. Predictor variables in these calculators have been clinical rather than biological, and our goal was to incorporate a neurochemical imaging measure into this framework and assess its impact on prediction. We combined striatal glutamate

Indexed as

Glutamic AcidPsychotic DisordersHumansProton Magnetic Resonance SpectroscopyRisk AssessmentROC CurveGlutamic AcidClinical high-riskConversion to psychosisGlutamateRisk calculator

Identifiers

PMID31522867
PMCPMC7065933
OpenAlexW2972699436

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.