Evidence map›Paper›PMID 31522810›Full record

ArticleJournal of endodontics2019

A Correlation between Wnt/Beta-catenin Signaling and the Rate of Dentin Secretion.

Yuan Zhao, Xue Yuan, Teresita Bellido, Jill A Helms

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of endodontics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yuan ZhaoDepartment of Cariology and Endodontology, School of Dentistry, Lanzhou University, Lanzhou, China; Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, California.
Xue YuanDivision of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, California.
Teresita BellidoDepartments of Anatomy and Cell Biology and Medicine, Division of Endocrinology, Indiana University School of Medicine and Roudebush Veterans Administration Medical Center, Indianapolis, Indiana.
Jill A HelmsDivision of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, California. Electronic address: jhelms@stanford.edu.

Funding

Mechanobiology at Healing Bone-Implant InterfacesR01DE024000 · NIDCR · STANFORD UNIVERSITY · PI BRUNSKI, JOHN BEYER, HELMS, JILL A · 2014 to 2018
$3.4M
Osteocyte control of bone formation via SostR01DK076007 · NIDDK · UNIV OF ARKANSAS FOR MED SCIS · PI BELLIDO, TERESITA M. · 2007 to 2010
$1.4M
BLRD VA I01 BX002104BLRD VA IK6 BX004596NIDCR NIH HHS R01 DE024000NIDDK NIH HHS R01 DK076007
6 · The paper itself

Abstract

introductionOdontoblasts produce dentin throughout life and in response to trauma. The purpose of this study was to identify the roles of endogenous Wnt signaling in regulating the rate of dentin accumulation.

methodsHistology, immunohistochemistry, vital dye labeling, and histomorphometric assays were used to quantify the rate of dentin accumulation as a function of age. Two strains of Wnt reporter mice were used to identify and follow the distribution and number of Wnt-responsive odontoblasts as a function of age. To show a causal relationship between dentin secretion and Wnt signaling, dentin accumulation was monitored in a strain of mice in which Wnt signaling was aberrantly elevated.

resultsDentin deposition occurs throughout life, but the rate of accumulation slows with age. This decline in dentin secretion correlates with a decrease in endogenous Wnt signaling. In a genetically modified strain of mice, instead of tubular dentin, aberrantly elevated Wnt signaling resulted in accumulation of reparative dentin or osteodentin secreted from predontoblasts.

conclusionsWnt signaling regulates dentin secretion by odontoblasts, and the formation of reparative or osteodentin is the direct consequence of elevated Wnt signaling. These preclinical data have therapeutic implications for the development of a biologically based pulp capping medicant.

Indexed as

beta CateninDentinWnt Signaling PathwayAnimalsDental PulpMiceOdontoblastsOdontogenesisbeta CateninAgingodontoblastspulpWnt signal

Identifiers

PMID31522810
PMCPMC10900857

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.