Evidence map›Paper›PMID 31522748›Full record

ArticleSurgery2019

Whole blood thrombin generation is distinct from plasma thrombin generation in healthy volunteers and after severe injury.

Julia R Coleman, Ernest E Moore, Jason M Samuels, Joshua J Ryon, Jesse T Nelson, Alexander Olson, Sandi Caus, Matthew G Bartley, Navin G Vigneshwar, Mitchell J Cohen and 3 more

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Trauma-induced coagulopathy.Nature reviews. Disease primers · 2021
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Julia R ColemanDepartment of Surgery, University of Colorado-Denver, Aurora, CO. Electronic address: julia.coleman@ucdenver.edu.
Ernest E MooreDepartment of Surgery, Ernest E Moore Shock Trauma Center at Denver Health, CO.
Jason M SamuelsDepartment of Surgery, University of Colorado-Denver, Aurora, CO.
Joshua J RyonDepartment of Surgery, Ernest E Moore Shock Trauma Center at Denver Health, CO.
Jesse T NelsonRosalind Franklin School of Medicine, North Chicago, IL.
Alexander OlsonDepartment of Biochemistry, University of Vermont, Burlington, VT.
Sandi CausDepartment of Biochemistry, University of Vermont, Burlington, VT.
Matthew G BartleyDepartment of Surgery, University of Colorado-Denver, Aurora, CO.
Navin G VigneshwarDepartment of Surgery, University of Colorado-Denver, Aurora, CO.
Mitchell J CohenDepartment of Surgery, Ernest E Moore Shock Trauma Center at Denver Health, CO.
Anirban BanerjeeDepartment of Surgery, University of Colorado-Denver, Aurora, CO.
Christopher C SillimanDepartment of Hematology, Children's Hospital of Colorado, Aurora, CO; Vitalant Research Institute, Denver, CO.
Saulius ButenasDepartment of Biochemistry, University of Vermont, Burlington, VT.
University of Colorado Denver · USUniversity of Vermont · USDenver Health Medical Center · USRosalind Franklin University of Medicine and Science · US

Funding

Analysis and Characterization of Trauma-Induced CoagulopathyUM1HL120877 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI MORRISSEY, JAMES H., WISNIEWSKI, STEPHEN R · 2013 to 2019
$26.6M
Trauma Reprograms CellsP50GM049222 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI BANERJEE, ANIRBAN · 1993 to 2017
$26.1M
Mechanisms of Trauma-Induced CoagulopathyT32GM008315 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Mitchell Cohen, ELIZABETH J. KOVACS · 1991 to 2026
$7.1M
NHLBI NIH HHS UM1 HL120877NIGMS NIH HHS P50 GM049222NIGMS NIH HHS T32 GM008315
6 · The paper itself

Abstract

backgroundPlasma thrombin generation has been used to characterize trauma-induced coagulopathy, but description of whole blood thrombin generation is lacking. This study aimed to evaluate plasma and whole blood thrombin generation in healthy volunteers and trauma patients. We hypothesized that (1) plasma and whole blood thrombin generation are distinct, (2) whole blood thrombin generation is more pronounced in trauma patients than in healthy volunteers, and (3) thrombin generation correlates with clinical coagulation assays.

methodsBlood was collected from healthy volunteers and trauma patients at a single, level-1 trauma center. Whole blood thrombin generation was assessed with a prototype point-of-care whole blood thrombin generation device, and plasma thrombin generation was measured with a calibrated automated thrombogram analogue. Plasma and whole blood thrombin generation were compared and correlated with international normalized ratio and thrombelastography.

resultsOverall, 10 healthy volunteers (average age 30, 50% men) were included and 58 trauma patients (average age 34, 76% men, 55% blunt mechanism, and with a median new injury severity score of 17) were included. Plasma and whole blood thrombin generation differed with more robust thrombin generation in plasma. Trauma patients had a significantly increased whole blood thrombin generation compared with healthy volunteers]. Plasma thrombin generation correlated with international normalized ratio, whereas whole blood thrombin generation did not correlate with thrombelastography.

conclusionPlasma and whole blood thrombin generation are distinct, highlighting the need to perform standardized assays to better understand their correlation and to assess how whole blood thrombin generation confers differential outcomes in trauma.

Indexed as

AdultBlood Coagulation DisordersFemaleHealthy VolunteersHumansInjury Severity ScoreMaleMiddle AgedPlasmaProspective StudiesThrombelastographyThrombinWounds and InjuriesThrombin

Identifiers

PMID31522748
PMCPMC6861673
OpenAlexW2973072196

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.