Evidence map›Paper›PMID 31522610›Full record

ArticleRNA biology2020

Tandem RNA isolation reveals functional rearrangement of RNA-binding proteins on

Valentina Iadevaia, Maikel D Wouters, Alexander Kanitz, Ana M Matia-González, Emma E Laing, André P Gerber

Open access · hybridAbstract read
In one paragraph

Article in RNA biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Towards an IdealInternational journal of molecular sciences · 2022
    Review
  6. Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Valentina IadevaiaDepartment of Microbial Sciences, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK.
Maikel D WoutersDepartment of Microbial Sciences, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK.
Alexander KanitzBiozentrum, University of Basel, Basel, Switzerland.ORCID 0000-0002-3468-0652
Ana M Matia-GonzálezDepartment of Microbial Sciences, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK.ORCID 0000-0002-8127-4219
Emma E LaingDepartment of Microbial Sciences, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK.
André P GerberDepartment of Microbial Sciences, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK.ORCID 0000-0002-2398-6592
University of Surrey · GBUniversity of Basel · CH

Funding

Biotechnology and Biological Sciences Research Council BB/K009303/1Biotechnology and Biological Sciences Research Council BB/N008820/1
6 · The paper itself

Abstract

Post-transcriptional control of gene expression is mediated via RNA-binding proteins (RBPs) that interact with mRNAs in a combinatorial fashion. While recent global RNA interactome capture experiments expanded the repertoire of cellular RBPs quiet dramatically, little is known about the assembly of RBPs on particular mRNAs; and how these associations change and control the fate of the mRNA in drug-treatment conditions. Here we introduce a novel biochemical approach, termed tobramycin-based tandem RNA isolation procedure (tobTRIP), to quantify proteins associated with the 3'UTRs of cyclin-dependent kinase inhibitor 1B (

Indexed as

3' Untranslated RegionsTandem Repeat SequencesCell Line, TumorCisplatinCyclin-Dependent Kinase Inhibitor p27Gene Expression RegulationGene Knockdown TechniquesHEK293 CellsHumansProtein BindingProtein Interaction MappingProtein Interaction MapsRNA-Binding ProteinsRNA, MessengerRNA Processing, Post-TranscriptionalRNA Stability3' Untranslated RegionsCisplatinCyclin-Dependent Kinase Inhibitor p27RNA-Binding ProteinsRNA, Messengerdrug responseKHSRPmRNA stabilityp27Post-transcriptional gene regulationRNA-binding protein

Identifiers

PMID31522610
PMCPMC6948961
OpenAlexW2973929047

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.