Evidence map›Paper›PMID 31522598›Full record

ArticleSLAS discovery : advancing life sciences R & D2020

Identification of Activators of Human Fumarate Hydratase by Quantitative High-Throughput Screening.

Hu Zhu, Olivia W Lee, Pranav Shah, Ajit Jadhav, Xin Xu, Samarjit Patnaik, Min Shen, Matthew D Hall

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in SLAS discovery : advancing life sciences R & D, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. The remodel of the "central dogma": a metabolomics interaction perspective.Metabolomics : Official journal of the Metabolomic Society · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Hu ZhuNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
Olivia W LeeNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
Pranav ShahNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
Ajit JadhavNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0001-7955-1451
Xin XuNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
Samarjit PatnaikNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
Min ShenNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
Matthew D HallNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0002-5073-442X
National Institutes of Health · US

Funding

NIH Chemical Genomics CenterZIBHG200319 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI AUSTIN, CHRISTOPHER P · 2010 to 2011
$55.9M
Pharmacokinetics and Drug MetabolismZIATR000369 · NCATS · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · PI XU, XIN · 2018 to 2025
$27.3M
Intramural NIH HHS ZIB HG200319
6 · The paper itself

Abstract

Fumarate hydratase (FH) is a metabolic enzyme that is part of the Krebs cycle and reversibly catalyzes the hydration of fumarate to malate. Mutations of the

Indexed as

High-Throughput Screening AssaysDose-Response Relationship, DrugDrug DiscoveryEnzyme ActivatorsFumarate HydrataseHumansKineticsOxidation-ReductionStructure-Activity RelationshipEnzyme ActivatorsFumarate Hydrataseautomationenzyme assaysenzyme kineticsfluorescence methodsroboticsultra-high-throughput screening

Identifiers

PMID31522598
PMCPMC7340117
OpenAlexW2972948052

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.