Evidence map›Paper›PMID 31522595›Full record

ArticleCell cycle (Georgetown, Tex.)2019

The crucial role of DNA-dependent protein kinase and myelin transcription factor 1-like protein in the miR-141 tumor suppressor network.

Bo Wang, Dongping Li, Youli Yao, Mieke Heyns, Anna Kovalchuk, Yaroslav Ilnytskyy, Rocio Rodriguez-Juarez, Roderick T Bronson, Gerlinde A S Metz, Olga Kovalchuk and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Bo WangDepartment of Biological Sciences, University of Lethbridge , Lethbridge , Canada.
Dongping LiDepartment of Biological Sciences, University of Lethbridge , Lethbridge , Canada.
Youli YaoDepartment of Agronomy, College of Agriculture, Yangzhou University , Yangzhou , P.R. China.
Mieke HeynsDepartment of Biological Sciences, University of Lethbridge , Lethbridge , Canada.
Anna KovalchukDepartment of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge , Lethbridge , Canada.
Yaroslav IlnytskyyDepartment of Biological Sciences, University of Lethbridge , Lethbridge , Canada.
Rocio Rodriguez-JuarezDepartment of Biological Sciences, University of Lethbridge , Lethbridge , Canada.
Roderick T BronsonRodent Histopathology Core, Harvard Medical School , Boston , MA , USA.
Gerlinde A S MetzDepartment of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge , Lethbridge , Canada.
Olga KovalchukDepartment of Biological Sciences, University of Lethbridge , Lethbridge , Canada.
Igor KovalchukDepartment of Biological Sciences, University of Lethbridge , Lethbridge , Canada.
University of Lethbridge · CAHarvard University · USYangzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma is the most aggressive brain tumor. Although miR-141 has been demonstrated to primarily function as a tumor suppressor in numerous malignancies, including glioblastoma, the mechanisms involved remain poorly understood. Here, it is shown that miR-141 is downregulated in glioblastoma cell lines and tissues and may exert its biological function via directly targeting

Indexed as

Cell Line, TumorCell ProliferationCyclin-Dependent Kinase Inhibitor p21DNA-Activated Protein KinaseDNA-Binding ProteinsGenes, Tumor SuppressorGlioblastomaHumansMicroRNAsNerve Tissue ProteinsS Phase Cell Cycle CheckpointsTranscription FactorsCDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p21DNA-Activated Protein KinaseDNA-Binding ProteinsMicroRNAsMIRN141 microRNA, humanMYT1L protein, humanMYT1 protein, humanNerve Tissue ProteinsPRKDC protein, humanTranscription Factorscell proliferationDNAPKGlioblastomamiR-141MYT1L

Identifiers

PMID31522595
PMCPMC6791708
OpenAlexW2974614940

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.