Evidence map›Paper›PMID 31522568›Full record

ReviewConnective tissue research2020

Glutathione as a mediator of cartilage oxidative stress resistance and resilience during aging and osteoarthritis.

Shouan Zhu, Dawid Makosa, Benjamin Miller, Timothy M Griffin

Open access · greenAbstract readReviewVideo-Audio Media
In one paragraph

Review in Connective tissue research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. Bioactive-RichBiomedicines · 2026
    Article
  3. The oral-gut-joint axis in osteoarthritis: a multiomics case-control study.Frontiers in cellular and infection microbiology · 2026
    Observational
  4. Article
  5. Article
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  13. Review
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  15. Article
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  18. Review
  19. Sirt3 Promotes Chondrogenesis, Chondrocyte Mitochondrial Respiration and the Development of High-Fat Diet-Induced Osteoarthritis in Mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Shouan ZhuAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Dawid MakosaAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Benjamin MillerAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Timothy M GriffinAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Oklahoma Medical Research Foundation · USUniversity of Oklahoma Health Sciences Center · USWarsaw University of Technology · PL

Funding

Targeted DNA Methylation and Mitochondrial Heteroplasmy CoreP30AG050911 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Matthew John Hart · 2015 to 2026
$13.9M
Chondrocyte Metabolic Stress in the Development of OsteoarthritisR01AG049058 · NIA · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI GRIFFIN, TIMOTHY M · 2015 to 2019
$1.9M
Activation of the Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase (SERCA) as a Therapeutic Intervention for SarcopeniaI01BX004453 · VA · OKLAHOMA CITY VA MEDICAL CENTER · PI VAN REMMEN, HOLLY · 2019 to 2022
–
BLRD VA I01 BX004453NIA NIH HHS P30 AG050911NIA NIH HHS R01 AG049058
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Oxidative StressAgingAnimalsCartilage, ArticularChondrocytesGlutathioneHumansOsteoarthritisRatsGlutathionecartilageglutathioneOsteoarthritisoxidative stressresiliencestress resistance

Identifiers

PMID31522568
PMCPMC6884680
OpenAlexW2973724894

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.