ArticleCirculation. Cardiovascular imaging2019
Changes in Cardiac Morphology and Function in Individuals With Diabetes Mellitus: The UK Biobank Cardiovascular Magnetic Resonance Substudy.
Article in Circulation. Cardiovascular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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37 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Pooled it
- The impact of lifestyle intervention on left atrial function in type 2 diabetes: results from the DIASTOLIC study.The international journal of cardiovascular imaging · 2022Trial
- Genetic deletion of MrgD receptor disrupts cardiac protein homeostasis in mice.Molecular biology reports · 2026Article
- Prognostic stratification of cardiovascular risk and cardiac remodeling in prediabetes: a multimodal analysis comparing ADA and WHO/IEC diagnostic criteria.Cardiovascular diabetology · 2026Observational
- Right and Left Atrial Dysfunction as Independent Cardiovascular Risk Factors: A UK Biobank Study.Circulation. Arrhythmia and electrophysiology · 2026Article
- Diabetes and cancer: therapeutic implications.Cardio-oncology (London, England) · 2026Review
- Valve cells are crucial for efficient cardiac performance in Drosophila.PLoS genetics · 2025Article
- The role of myocardial energy metabolism perturbations in diabetic cardiomyopathy: from the perspective of novel protein post-translational modifications.Clinical epigenetics · 2025Review
- Genetic basis of right and left ventricular heart shape.Nature communications · 2024Article
- Multi-modal characterisation of early-stage, subclinical cardiac deterioration in patients with type 2 diabetes.Cardiovascular diabetology · 2024Article
- Association between subclinical right ventricular alterations and aerobic exercise capacity in type 2 diabetes.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2024Article
- Assessment of left atrioventricular coupling and left atrial function impairment in diabetes with and without hypertension using CMR feature tracking.Cardiovascular diabetology · 2023Article
- Eyes and the heart: what a clinician should know.Heart (British Cardiac Society) · 2023Review
- Associations between eGFR and albuminuria with right ventricular measures: the MESA-Right Ventricle study.Clinical kidney journal · 2023Article
- Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images.Science (New York, N.Y.) · 2023Article
- The independent association of myocardial extracellular volume and myocardial blood flow with cardiac diastolic function in patients with type 2 diabetes: a prospective cross-sectional cohort study.Cardiovascular diabetology · 2023Article
- Impact of glycemic control on biventricular function in patients with type 2 diabetes mellitus: a cardiac magnetic resonance tissue tracking study.Insights into imaging · 2023Article
- Female is Associated with Left Ventricular Diastolic Dysfunction in Patients with Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Three-Dimensional Automated, Machine-Learning-Based Left Heart Chamber Metrics: Associations with Prevalent Vascular Risk Factors and Cardiovascular Diseases.Journal of clinical medicine · 2022Article
- Left atrial structure and function are associated with cardiovascular outcomes independent of left ventricular measures: a UK Biobank CMR study.European heart journal. Cardiovascular Imaging · 2022Article
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18 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundDiabetes mellitus (DM) is associated with increased risk of cardiovascular disease. Detection of early cardiac changes before manifest disease develops is important. We investigated early alterations in cardiac structure and function associated with DM using cardiovascular magnetic resonance imaging.
methodsParticipants from the UK Biobank Cardiovascular Magnetic Resonance Substudy, a community cohort study, without known cardiovascular disease and left ventricular ejection fraction ≥50% were included. Multivariable linear regression models were performed. The investigators were blinded to DM status.
resultsA total of 3984 individuals, 45% men, (mean [SD]) age 61.3 (7.5) years, hereof 143 individuals (3.6%) with DM. There was no difference in left ventricular (LV) ejection fraction (DM versus no DM; coefficient [95% CI]: -0.86% [-1.8 to 0.5];
conclusionsIn a low-risk general population without known cardiovascular disease and with preserved LV ejection fraction, DM is associated with early changes in all 4 cardiac chambers. These findings suggest that diabetic cardiomyopathy is not a regional condition of the LV but affects the heart globally.
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