ArticleJournal of biomedical optics2019
Single-shot two-frame π-shifted spatially multiplexed interference phase microscopy.
Article in Journal of biomedical optics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Off-axis digital lensless holographic microscopy based on spatially multiplexed interferometry.Journal of biomedical optics · 2024Article
- Single-shot wavelength-multiplexed phase microscopy under Gabor regime in a regular microscope embodiment.Scientific reports · 2023Article
- Common-path intrinsically achromatic optical diffraction tomography.Biomedical optics express · 2021Article
- Variational Hilbert Quantitative Phase Imaging.Scientific reports · 2020Article
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5 authors.
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Abstract
Single-shot, two-frame, π-shifted spatially multiplexed interference microscopy (π-SMIM) is presented as an improvement to previous SMIM implementations, introducing a versatile, robust, fast, and accurate method for cumbersome, noisy, and low-contrast phase object analysis. The proposed π-SMIM equips a commercially available nonholographic microscope with a high-speed (video frame rate) enhanced quantitative phase imaging (QPI) capability by properly placing a beam-splitter in the microscope embodiment to simultaneously (in a single shot) record two holograms mutually phase shifted by π radians at the expense of reducing the field of view. Upon subsequent subtractive superimposition of holograms, a π-hologram is generated with reduced background and improved modulation of interference fringes. These features determine superior phase retrieval quality, obtained by employing the Hilbert spiral transform on the π-hologram, as compared with a single low-quality (low signal-to-noise ratio) hologram analysis. In addition, π-SMIM enables accurate in-vivo analysis of high dynamic range phase objects, otherwise measurable only in static regime using time-consuming phase-shifting. The technique has been validated utilizing a 20 × / 0.46 NA objective in a regular Olympus BX-60 upright microscope for QPI of different lines of prostate cancer cells and flowing microbeads.
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