Evidence map›Paper›PMID 31522323›Full record

ArticleDigestive diseases and sciences2020

Alvimopan for the Prevention of Postoperative Ileus in Inflammatory Bowel Disease Patients.

Janice Jang, Benjamin Kwok, Hua Zhong, Yuhe Xia, Alexis Grucela, Mitchell Bernstein, Feza Remzi, David Hudesman, Jingjing Chen, Jordan Axelrad and 1 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Digestive diseases and sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04405037 (A Prospective Randomized Control Trial of The Effectiveness of Alvimopan as a Rescue Treatment of Postoperative Ileus Following Colorectal Surgery), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04405037 phase4completednot on this map

A Prospective Randomized Control Trial of The Effectiveness of Alvimopan as a Rescue Treatment of Postoperative Ileus Following Colorectal Surgery

TypeinterventionalSponsorScott SteeleRan2020 to 2024Enrolled65ConditionsIleus, Gastrointestinal DysfunctionArmsAlvimopan
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Selective Opioid Antagonists Following Bowel Resection for Prevention of Postoperative Ileus: a Systematic Review and Meta-analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021
    Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Janice JangDivision of Gastroenterology and Hepatology, New York University Langone Health, 240 East 38th Street, 23rd Floor, New York, NY, 10016, USA.
Benjamin KwokDepartment of Internal Medicine, New York University Langone Health, New York, NY, USA.
Hua ZhongDepartment of Population Health, New York University Langone Health, New York, NY, USA.
Yuhe XiaDepartment of Population Health, New York University Langone Health, New York, NY, USA.
Alexis GrucelaDepartment of Surgery, New York University Langone Health, New York, NY, USA.
Mitchell BernsteinDepartment of Surgery, New York University Langone Health, New York, NY, USA.
Feza RemziDepartment of Surgery, New York University Langone Health, New York, NY, USA.
David HudesmanDivision of Gastroenterology and Hepatology, New York University Langone Health, 240 East 38th Street, 23rd Floor, New York, NY, 10016, USA.
Jingjing ChenDepartment of Internal Medicine, Stanford University Medical Center, Stanford, CA, USA.
Jordan AxelradDivision of Gastroenterology and Hepatology, New York University Langone Health, 240 East 38th Street, 23rd Floor, New York, NY, 10016, USA.
Shannon ChangDivision of Gastroenterology and Hepatology, New York University Langone Health, 240 East 38th Street, 23rd Floor, New York, NY, 10016, USA. Shannon.Chang@nyulangone.org.
NYU Langone Health · USStanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative ileus (POI) is a temporary delay of coordinated intestinal peristalsis. Alvimopan, an oral peripherally acting mu-opioid receptor antagonist approved for accelerating gastrointestinal recovery, has never been studied specifically in patients with inflammatory bowel disease (IBD).

aimTo investigate the efficacy of alvimopan in preventing POI among IBD patients.

methodsA retrospective chart review was conducted on 246 IBD patients undergoing bowel surgery between 2012 and 2017. Data collected included demographics, IBD subtype, length of stay (LOS), postoperative gastrointestinal symptoms, and administration of alvimopan. The primary outcome was POI; secondary gastrointestinal recovery outcomes were: time to first flatus, time to first bowel movement, time to tolerating a liquid diet, time to tolerating solid food, and LOS.

resultsWhen compared with the control group, patients in the alvimopan group had shorter times to tolerating liquids and solids, first flatus, and first bowel movements (p < 0.01). LOS was shorter in the alvimopan group when compared with controls (p < 0.01). The overall incidence of POI was higher in controls than in the alvimopan group (p = 0.07). For laparoscopic surgeries, the incidence of POI was also higher in controls than in the alvimopan group (p < 0.01). On multivariable analysis, alvimopan significantly decreased time to all gastrointestinal recovery endpoints when compared to controls (p < 0.01).

conclusionsAlvimopan is effective in accelerating time to gastrointestinal recovery and reducing POI in IBD patients. While the benefits of alvimopan have been demonstrated previously, this is the first study of the efficacy of alvimopan in IBD patients.

Indexed as

AdultFemaleGastrointestinal AgentsHumansIleusInflammatory Bowel DiseasesMaleMiddle AgedPiperidinesPostoperative ComplicationsRetrospective StudiesalvimopanGastrointestinal AgentsPiperidinesAlvimopanBowel surgeryCrohn’s diseaseGastrointestinal recoveryPostoperative ileusUlcerative colitis

Identifiers

PMID31522323
OpenAlexW2973064769

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.