Evidence map›Paper›PMID 31522255›Full record

ReviewChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2019

The molecular oncology of bilateral high-grade thalamic astrocytomas in children.

Amir Goodarzi, Nicholas Garza, Mirna Lechpammer, Reuben Anthony, Marike Zwienenberg

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Amir GoodarziDepartments of Neurological Surgery, University of California, Davis, Sacramento, CA, USA. agoodarzi@ucdavis.edu.ORCID 0000-0002-7160-5037
Nicholas GarzaSchool of Medicine, University of California, Davis, Sacramento, CA, USA.
Mirna LechpammerDepartment of Pathology, University of California, Davis, Sacramento, CA, USA.
Reuben AnthonyDepartment of Pediatric Hematology-Oncology, University of California, Davis, Sacramento, CA, USA.
Marike ZwienenbergDepartments of Neurological Surgery, University of California, Davis, Sacramento, CA, USA.
University of California, Davis · USNeurological Surgery · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBilateral thalamic astrocytomas in children are exceedingly rare. These highly malignant tumors seldom respond to conventional treatment strategies and carry a grim prognosis for patients. However, recent advances in molecular oncology have had a positive impact on prognostication and treatment strategies of these tumors. CASE-BASED REVIEW: We present a new case of WHO grade III bilateral thalamic astrocytoma in a child and review the pathophysiology, molecular oncogenesis, and relevant treatment strategies for this rare disease.

conclusionsHigh-grade thalamic astrocytomas affecting both thalami pose a challenge to pediatric neurosurgeons, neuro-oncologists, and neuropathologists given the lack of effective treatment strategies. Understanding recent revelations in the field of molecular oncology can assist clinicians in adequately formulating a treatment plan in this patient population.

Indexed as

AstrocytomaBrain NeoplasmsChildHumansMaleNeoplasm GradingThalamusGliomaHistonesMolecularOncology

Identifiers

PMID31522255
OpenAlexW2972376312

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.