ArticleChild abuse & neglect2019
Examining the link between emotional childhood abuse and social relationships in midlife: The moderating role of the oxytocin receptor gene.
Article in Child abuse & neglect, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Tracing the paths: a systematic review of mediators of complex trauma and complex post-traumatic stress disorder.Frontiers in psychiatry · 2024Pooled it
- An unbreakable bond? Maternal adverse childhood experiences and mothers' relationships with adult children.Social forces; a scientific medium of social study and interpretation · 2025Article
- Linking childhood trauma to the psychopathology of schizophrenia: the role of oxytocin.Schizophrenia (Heidelberg, Germany) · 2024Article
- Examining the relationship between genetic risk for depression and youth episodic stress exposure.Journal of affective disorders · 2023Article
- Early life adversity and adult social relationships have independent effects on survival in a wild primate.Science advances · 2023Article
- The interaction of the oxytocin receptor gene and child abuse subtypes on social cognition in euthymic patients with bipolar disorder type I.Frontiers in psychiatry · 2023Article
- Childhood Emotional Neglect Is Associated With Low Social Support in Chinese Patients With Major Depressive Disorder.Frontiers in psychiatry · 2021Article
- Childhood Trauma and Aggression in Persons Convicted for Homicide: An Exploratory Study Examines the Role of Plasma Oxytocin.Frontiers in psychiatry · 2021Article
- Social bonds do not mediate the relationship between early adversity and adult glucocorticoids in wild baboons.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Childhood Adversities as Determinants of Cardiovascular Disease Risk and Perceived Illness Burden in Adulthood: Comparing Retrospective and Prospective Self-Report Measures in a Longitudinal Sample of African Americans.Journal of youth and adolescence · 2020Article
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5 authors.
Funding
Abstract
backgroundA single nucleotide polymorphism (SNP), rs53576, of the oxytocin receptor gene (OXTR) has been associated with fundamental aspects of social processes and behaviors. Compared to A carriers, GG individuals have enhanced social competencies and tend to elicit more positive responses from social partners. However, the G allele of the OXTR rs53576 has also been associated with greater social sensitivity.
objectiveThe current study examined the unique influence of emotional childhood abuse on positive and negative aspects of different types of social relationships (e.g., family, spouse/partner, and friends) in midlife and whether genetic variations of OXTR rs53576 moderated these associations. PARTICIPANTS AND
settingA total of 614 participants in midlife (aged 40-65), recruited for a large-scale study of Phoenix metropolitan residents (AS U Live Project), answered self-report questionnaires and provided blood samples for DNA genotyping.
methodsHierarchical multiple regression analyses tested whether emotional childhood abuse predicted social support and strain for each relationship type and whether these potential linkages differed by OXTR genotype (GG versus AA/AG).
resultsOverall, individuals with a history of emotional childhood abuse had less supportive and more strained relationships in midlife. For supportive family relationships, the effect of emotional childhood abuse was moderated by OXTR rs53576 (p < .001). Under conditions of experiencing more emotional abuse in childhood, GG individuals had more supportive family relationships in midlife compared to A carriers.
conclusionsOverall, genetic variations of OXTR rs53576 may be an important candidate in understanding the development of social functioning within the context of emotional childhood abuse.
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