Evidence map›Paper›PMID 31521775›Full record

Observational studyResuscitation2019

Cardiac arrest in the intensive care unit: An assessment of preventability.

Ari Moskowitz, Katherine M Berg, Michael N Cocchi, Maureen Chase, Jesse X Yang, Jennifer Sarge, Anne V Grossestreuer, Todd Sarge, Sharon O' Donoghue, Michael W Donnino

Abstract readObservational Study
In one paragraph

Observational study in Resuscitation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Ten Steps Toward Improving In-Hospital Cardiac Arrest Quality of Care and Outcomes.Circulation. Cardiovascular quality and outcomes · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. [Adult advanced life support].Notfall & rettungsmedizin · 2021
    Review
  16. eStablish And Formalize Expert Criteria for Avoidable Resuscitation Review (SAFECARR) Electronic Delphi: Development of a Consensus Framework for Classifying and Reviewing Cardiac Arrests Within the PICU.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Ari MoskowitzBeth Israel Deaconess Medical Center, Division of Pulmonary, Critical Care and Sleep Medicine, Boston, MA, United States.
Katherine M BergBeth Israel Deaconess Medical Center, Division of Pulmonary, Critical Care and Sleep Medicine, Boston, MA, United States.
Michael N CocchiBeth Israel Deaconess Medical Center, Division of Anesthesia Critical Care, Boston, MA, United States; Beth Israel Deaconess Medical Center, Department of Emergency Medicine, Boston, MA, United States.
Maureen ChaseBeth Israel Deaconess Medical Center, Department of Emergency Medicine, Boston, MA, United States.
Jesse X YangBeth Israel Deaconess Medical Center, Division of Cardiology, Boston, MA, United States.
Jennifer SargeBeth Israel Deaconess Medical Center, Critical Care Nursing, Boston, MA, United States.
Anne V GrossestreuerBeth Israel Deaconess Medical Center, Department of Emergency Medicine, Boston, MA, United States.
Todd SargeBeth Israel Deaconess Medical Center, Division of Anesthesia Critical Care, Boston, MA, United States.
Sharon O' DonoghueBeth Israel Deaconess Medical Center, Division of Cardiology, Boston, MA, United States.
Michael W DonninoBeth Israel Deaconess Medical Center, Division of Pulmonary, Critical Care and Sleep Medicine, Boston, MA, United States; Beth Israel Deaconess Medical Center, Department of Emergency Medicine, Boston, MA, United States. Electronic address: mdonnino@bidmc.harvard.edu.
Beth Israel Deaconess Medical Center · US

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
Thaimine as an adjunct metabolic resuscitator in cardiac arrestK24HL127101 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI DONNINO, MICHAEL WILLIAM · 2015 to 2024
$1.2M
Thiamine v placebo to improve oxygen consumption after in-hospital cardiac arrestK23HL128814 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BERG, KATHERINE M · 2016 to 2021
$1.0M
Thiamine as a Renal Protective Agent in Septic ShockK23GM128005 · NIGMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MOSKOWITZ, ARI · 2018 to 2021
$761k
NHLBI NIH HHS K23 HL128814NHLBI NIH HHS K24 HL127101NIGMS NIH HHS K23 GM128005
6 · The paper itself

Abstract

aimCardiac arrest in the intensive care unit (ICU-CA) is a common and highly morbid event. We investigated the preventability of ICU-CAs and identified targets for future intervention.

methodsThis was a prospective, observational study of ICU-CAs at a tertiary care center in the United States. For each arrest, the clinical team was surveyed regarding arrest preventability. An expert, multi-disciplinary team of physicians and nurses also reviewed each arrest. Arrests were scored 0 (not at all preventable) to 5 (completely preventable). Arrests were considered 'unlikely but potentially preventable' or 'potentially preventable' if at least 50% of reviewers assigned a score of ≥1 or ≥3 respectively. Themes of preventability were assessed for each arrest.

results43 patients experienced an ICU-CA and were included. A total of 14 (32.6%) and 13 (30.2%) arrests were identified as unlikely but potentially preventable by the expert panel and survey respondents respectively, and an additional 11 (25.6%) and 10 (23.3%) arrests were identified as potentially preventable. Timing of response to clinical deterioration, missed/incorrect diagnosis, timing of acidemia correction, timing of escalation to a more senior clinician, and timing of intubation were the most commonly cited contributors to potential preventability. Additional themes identified included the administration of anxiolytics/narcotics for agitation later identified to be due to clinical deterioration and misalignment between team and patient/family perceptions of prognosis and goals-of-care.

conclusionsICU-CAs may have preventable elements. Themes of preventability were identified and addressing these themes through data-driven quality improvement initiatives could potentially reduce CA incidence in critically-ill patients.

Indexed as

AgedCardiopulmonary ResuscitationClinical DeteriorationFemaleHeart ArrestHumansIntensive Care UnitsMaleMiddle AgedOrganizational Case StudiesProspective StudiesQualitative ResearchQuality ImprovementSurveys and QuestionnairesTime FactorsCardiopulmonary resuscitationCritical careHeart arrestIntensive care unit quality improvement

Identifiers

PMID31521775
PMCPMC7076735
OpenAlexW2972478779

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.