ReviewNeuroscience and biobehavioral reviews2019
Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning.
Review in Neuroscience and biobehavioral reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 88 citations in OpenAlex.
- Understanding the Role of Endocannabinoids in Posttraumatic Stress Disorder.International journal of molecular sciences · 2025Review
- Hippocampal Involvement in Safety Signal Learning Varies With Anxiety Among Healthy Adults.Biological psychiatry global open science · 2024Article
- Context reexposure to bolster contextual dependency of emotional episodic memory.Scientific reports · 2023Article
- The Role of Serotonin in Fear Learning and Memory: A Systematic Review of Human Studies.Brain sciences · 2023Review
- Examining the impact of cue similarity and fear learning on perceptual tuning.Scientific reports · 2023Article
- Evidence of Altered Fear Extinction Learning in Individuals with High Vaccine Hesitancy During Covid-19 Pandemic.Clinical neuropsychiatry · 2023Article
- Age-specific sex effects in extinction of conditioned fear in rodents.Frontiers in behavioral neuroscience · 2023Article
- VR for Studying the Neuroscience of Emotional Responses.Current topics in behavioral neurosciences · 2023Article
- Understanding clinical fear and anxiety through the lens of human fear conditioning.Nature reviews psychology · 2023Review
- How Different Factors in Combination Change Fear Extinction Learning: The Case of Sex and Stress Hormones.Current topics in behavioral neurosciences · 2023Article
- Beyond Fear, Extinction, and Freezing: Strategies for Improving the Translational Value of Animal Conditioning Research.Current topics in behavioral neurosciences · 2023Article
- Measuring human trace fear conditioning.Psychophysiology · 2022Article
- Pattern analysis of neuroimaging data reveals novel insights on threat learning and extinction in humans.Neuroscience and biobehavioral reviews · 2022Review
- Stimulation of the ventromedial prefrontal cortex blocks the return of subcortically mediated fear responses.Translational psychiatry · 2022Article
- Postural freezing relates to startle potentiation in a human fear-conditioning paradigm.Psychophysiology · 2022Article
- Involvement of D2-like dopaminergic receptors in contextual fear conditioning in female rats: influence of estrous cycle.Frontiers in behavioral neuroscience · 2022Article
- Robust BOLD Responses to Faces But Not to Conditioned Threat: Challenging the Amygdala's Reputation in Human Fear and Extinction Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Observation of others' threat reactions recovers memories previously shaped by firsthand experiences.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Enhanced contextual fear memory in peroxiredoxin 6 knockout mice is associated with hyperactivation of MAPK signaling pathway.Molecular brain · 2021Article
- Absence Makes the Mind Grow Fonder: Reconceptualizing Studies of Safety Learning in Translational Research on Anxiety.Cognitive, affective & behavioral neuroscience · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 10 institutions in 4 countries.
Funding
Abstract
Translational neuroscience bridges insights from specific mechanisms in rodents to complex functions in humans and is key to advance our general understanding of central nervous function. A prime example of translational research is the study of cross-species mechanisms that underlie responding to learned threats, by employing Pavlovian fear conditioning protocols in rodents and humans. Hitherto, evidence for (and critique of) these cross-species comparisons in fear conditioning research was based on theoretical viewpoints. Here, we provide a perspective to substantiate these theoretical concepts with empirical considerations of cross-species methodology. This meta-research perspective is expected to foster cross-species comparability and reproducibility to ultimately facilitate successful transfer of results from basic science into clinical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.