Evidence map›Paper›PMID 31521672›Full record

ArticleChest2020

Estimated Ventricular Size, Asthma Severity, and Exacerbations: The Severe Asthma Research Program III Cohort.

Samuel Y Ash, Gonzalo Vegas Sanchez-Ferrero, Mark L Schiebler, Farbod N Rahaghi, Ashish Rai, Carolyn E Come, James C Ross, Alysha G Colon, Juan Carlos Cardet, Eugene R Bleecker and 15 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chest, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01761630 (ALXR/FPR Mediated Signaling in Severe Asthma), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01761630 completednot on this map

ALXR/FPR Mediated Signaling in Severe Asthma (AMSA)-The Severe Asthma Research Program (SARP) III

TypeobservationalSponsorElliot Israel, MDRan2012 to 2021Enrolled126ConditionsAsthma
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. The emerging role of quantitative imaging in asthma.The British journal of radiology · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 13 institutions in 1 country.

Samuel Y AshDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA; Applied Chest Imaging Laboratory, Brigham and Women's Hospital, Boston, MA. Electronic address: syash@bwh.harvard.edu.
Gonzalo Vegas Sanchez-FerreroApplied Chest Imaging Laboratory, Brigham and Women's Hospital, Boston, MA.
Mark L SchieblerDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Farbod N RahaghiDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA; Applied Chest Imaging Laboratory, Brigham and Women's Hospital, Boston, MA.
Ashish RaiDepartment of Medicine, North Shore Medical Center, Salem, MA.
Carolyn E ComeDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA; Applied Chest Imaging Laboratory, Brigham and Women's Hospital, Boston, MA.
James C RossApplied Chest Imaging Laboratory, Brigham and Women's Hospital, Boston, MA.
Alysha G ColonCollege of Medicine, University of Florida, Gainesville, FL.
Juan Carlos CardetDivision of Allergy and Immunology, Department of Medicine, University of South Florida, Tampa, FL.
Eugene R BleeckerDivision of Genetics, Genomics and Precision Medicine, University of Arizona, Tucson, AZ.
Mario CastroDivision of Pulmonary and Critical Care Medicine, Washington University, St. Louis, MO.
John V FahyDivision of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, CA.
Sean B FainDepartments of Medical Physics, Radiology, and Biomedical Engineering, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Benjamin M GastonDivision of Pulmonology, Allergy, and Immunology, and Pediatric Pulmonology, Rainbow Babies and Children's Hospital and Cleveland Medical Center, Cleveland, OH.
Eric A HoffmanDepartments of Radiology, Biomedical Engineering, and Medicine, University of Iowa, Iowa City, IA.
Nizar N JarjourDivision of Pulmonary and Critical Care Medicine (Dr Jarjour), University of Wisconsin School of Medicine and Public Health, Madison, WI.
Jason K LempelDepartment of Radiology, Cleveland Clinic, Cleveland, OH.
David T MaugerDivision of Biostatistics and Bioinformatics, Penn State Eberly College of Science, University Park, PA.
Matthew C TattersallDivision of Cardiovascular Medicine (Dr Tattersall), University of Wisconsin School of Medicine and Public Health, Madison, WI.
Sally E WenzelDivision of Pulmonary, Allergy and Critical Care, University of Pittsburgh, Pittsburgh, PA.
Bruce D LevyDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA.
George R WashkoDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA; Applied Chest Imaging Laboratory, Brigham and Women's Hospital, Boston, MA.
Elliot IsraelDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA.
Raul San Jose EsteparApplied Chest Imaging Laboratory, Brigham and Women's Hospital, Boston, MA.
SARP Investigators
Brigham and Women's Hospital · USUniversity of Wisconsin–Madison · USPennsylvania State University · USUniversity of Pittsburgh · USCleveland Clinic · USRainbow Babies & Children's Hospital · USUniversity of Arizona · USUniversity of California, San Francisco · USWashington University in St. Louis · USNorth Shore Medical Center · USUniversity of Florida · USUniversity of Iowa · USUniversity of South Florida · US

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5M
Rapid saliva antigen test for SARS-CoV-2 detectionU01HL146002 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ARONICA, MARK A, CASTRO, MARIO · 2019 to 2023
$17.3M
RESPIRATORY RESEARCHT32HL007633 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI George R Washko · 1985 to 2026
$14.9M
Clinical Coordinating Center for the Severe Asthma Research Program (SARP)U10HL109086 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI MAUGER, DAVID T. · 2011 to 2017
$8.1M
The clinical impact of pulmonary vascular remodeling in smokersR01HL116473 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SAN JOSE ESTEPAR, RAUL, WASHKO, GEORGE R · 2013 to 2021
$5.0M
Specialized Pro-Resolving Mediators in AsthmaR01HL122531 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LEVY, BRUCE D · 2014 to 2024
$4.7M
NCATS NIH HHS UL1 TR000427NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR001102NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR002345NCATS NIH HHS UL1 TR002373NHLBI NIH HHS K08 HL145118NHLBI NIH HHS K23 HL114735NHLBI NIH HHS K23 HL136905NHLBI NIH HHS L30 HL134158NHLBI NIH HHS R01 HL116473NHLBI NIH HHS R01 HL116931NHLBI NIH HHS R01 HL122464NHLBI NIH HHS R01 HL122531NHLBI NIH HHS T32 HL007633NHLBI NIH HHS U01 HL146002NHLBI NIH HHS U10 HL109086NHLBI NIH HHS U10 HL109146NHLBI NIH HHS U10 HL109152NHLBI NIH HHS U10 HL109164NHLBI NIH HHS U10 HL109168NHLBI NIH HHS U10 HL109172NHLBI NIH HHS U10 HL109250NHLBI NIH HHS U10 HL109257NIAID NIH HHS K23 AI125785NIDDK NIH HHS P30 DK054759NIH HHS S10 OD018526
6 · The paper itself

Abstract

backgroundRelative enlargement of the pulmonary artery (PA) on chest CT imaging is associated with respiratory exacerbations in patients with COPD or cystic fibrosis. We sought to determine whether similar findings were present in patients with asthma and whether these findings were explained by differences in ventricular size.

methodsWe measured the PA and aorta diameters in 233 individuals from the Severe Asthma Research Program III cohort. We also estimated right, left, and total epicardial cardiac ventricular volume indices (eERVVI, eELVVI, and eETVVI, respectively). Associations between the cardiac and PA measures (PA-to-aorta [PA/A] ratio, eERVVI-to-eELVVI [eRV/eLV] ratio, eERVVI, eELVVI, eETVVI) and clinical measures of asthma severity were assessed by Pearson correlation, and associations with asthma severity and exacerbation rate were evaluated by multivariable linear and zero-inflated negative binomial regression.

resultsAsthma severity was associated with smaller ventricular volumes. For example, those with severe asthma had 36.1 mL/m

conclusionsIn patients with asthma, smaller cardiac ventricular size may be associated with more severe disease and a higher rate of asthma exacerbations. TRIAL REGISTRY: ClinicalTrials.gov; No.: NCT01761630; URL: www.clinicaltrials.gov.

Indexed as

AdultAortaAsthmaCase-Control StudiesCone-Beam Computed TomographyDisease ProgressionFemaleForced Expiratory VolumeHeart VentriclesHumansLogistic ModelsMaleMiddle AgedOrgan SizePulmonary ArterySeverity of Illness IndexasthmaCT imagingheart

Identifiers

PMID31521672
PMCPMC7005378
OpenAlexW2981727269

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.