ArticleCell systems2019
The Design Principles of Biochemical Timers: Circuits that Discriminate between Transient and Sustained Stimulation.
Article in Cell systems, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
- Transient frequency preference responses in cell signaling systems.NPJ systems biology and applications · 2024Article
- The Topological Characteristics of Biological Ratio-Sensing Networks.Life (Basel, Switzerland) · 2023Article
- A synthetic biology approach reveals diverse and dynamic CDK response profiles via multisite phosphorylation of NLS-NES modules.Science advances · 2022Article
- Time-series transcriptomics and proteomics reveal alternative modes to decode p53 oscillations.Molecular systems biology · 2022Article
- A synthetic gene circuit for imaging-free detection of signaling pulses.Cell systems · 2022Article
- Controlling gene expression timing through gene regulatory architecture.PLoS computational biology · 2022Article
- Cyclin/Forkhead-mediated coordination of cyclin waves: an autonomous oscillator rationalizing the quantitative model of Cdk control for budding yeast.NPJ systems biology and applications · 2021Review
- Can thiol-based redox systems be utilized as parts for synthetic biology applications?Redox report : communications in free radical research · 2021Article
- Cell-Free Characterization of Coherent Feed-Forward Loop-Based Synthetic Genetic Circuits.ACS synthetic biology · 2021Article
- A rationally engineered decoder of transient intracellular signals.Nature communications · 2021Article
- Keeping track of time: The fundamentals of cellular clocks.The Journal of cell biology · 2020Review
- Multi-model and network inference based on ensemble estimates: avoiding the madness of crowds.Journal of the Royal Society, Interface · 2020Article
- Engineering combinatorial and dynamic decoders using synthetic immediate-early genes.Communications biology · 2020Article
- Article
- Adapting machine-learning algorithms to design gene circuits.BMC bioinformatics · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Many cellular responses for which timing is critical display temporal filtering-the ability to suppress response until stimulated for longer than a given minimal time. To identify biochemical circuits capable of kinetic filtering, we comprehensively searched the space of three-node enzymatic networks. We define a metric of "temporal ultrasensitivity," the steepness of activation as a function of stimulus duration. We identified five classes of core network motifs capable of temporal filtering, each with distinct functional properties such as rejecting high-frequency noise, committing to response (bistability), and distinguishing between long stimuli. Combinations of the two most robust motifs, double inhibition (DI) and positive feedback with AND logic (PF
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.