ReviewTrends in endocrinology and metabolism: TEM2019
Hormesis in Health and Chronic Diseases.
Review in Trends in endocrinology and metabolism: TEM, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Influence of Age and Dose on the Effect of Resveratrol for Glycemic Control in Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis.Molecules (Basel, Switzerland) · 2022Pooled it
- Trial
- Article
- Temporal Effects of Cigarette Smoke and Phytochemical-Based E-Liquid Aerosols on Tracheo-Alveolar Histopathology and the IL-6/TNF-α Molecular Signaling Axis.Current issues in molecular biology · 2026Article
- Maternal Obesity Programs Adipogenic Commitment in Neonatal Mesenchymal Stem Cells: A Link to Redox-Dependent FOXO1 Signaling.Journal of cellular physiology · 2026Article
- Review
- Treadmill Exercise Modulates the Leptin/LepR/GSK-3β Signalling Pathway to Improve Leptin Sensitivity and Alleviate Neuroinflammation in High-Fat Diet-Fed APP/PS1 Mice.Molecular neurobiology · 2025Article
- Muscle Rev-erb controls time-dependent adaptations to chronic exercise in mice.Nature communications · 2025Article
- Modulation of the Adaptive Capacity of Growing Rats through Modification of the Protein Content in the Diet.Bulletin of experimental biology and medicine · 2025Article
- Article
- Nanoparticle-EMF synergism: a study on the combined effects on developmental and behavioral endpoints inFrontiers in public health · 2025Article
- From frailty to resilience: exploring adaptive capacity and reserve in older adults-a narrative review.Frontiers in aging · 2025Review
- Low-dose estrogen release from silastic capsule enhanced flap wound healing in an animal model.International wound journal · 2024Article
- The toxic effects ofFood science & nutrition · 2024Article
- Myxedema in Both Hyperthyroidism and Hypothyroidism: A Hormetic Response?International journal of molecular sciences · 2024Article
- Redox regulation of UPR signalling and mitochondrial ER contact sites.Cellular and molecular life sciences : CMLS · 2024Review
- Greater socioenvironmental risk factors and higher chronic pain stage are associated with thinner bilateral temporal lobes.Brain and behavior · 2023Article
- Elucidating individual differences in chronic pain and whole person health with allostatic load biomarkers.Brain, behavior, & immunity - health · 2023Article
- The Hormesis Concept: Strengths and Shortcomings.Biomolecules · 2023Review
- The Impact of Hormesis, Neuronal Stress Response, and Reproduction, upon Clinical Aging: A Narrative Review.Journal of clinical medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
'What doesn't kill you makes you stronger'. Hormesis, the paradoxical beneficial effects of low-dose stressors, can be better defined as the biphasic dose-effect or time-effect relationship for any substance. Here we review hormesis-like phenomena in the context of chronic diseases for many substances, including lifestyle factors and endocrine factors. Intermittent or pulsatile exposure can generate opposite effects compared with continuous exposure. An initial exposure can elicit an adaptive stress response with long-lasting protection against subsequent exposures. Early-life stress can increase resilience in later life and lack of stress can lead to vulnerability. Many stressors are naturally occurring and are required for healthy growth or homeostasis, which exemplifies how 'illness is the doorway to health'.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.