ArticleJournal of neuroengineering and rehabilitation2019
Neuromuscular adaptations and sensorimotor integration following a unilateral transfemoral amputation.
Article in Journal of neuroengineering and rehabilitation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- Biomechanical Analysis of an Elite Para Standing Cross-Country Skier Using Lower Limb Prostheses: A Case Study.Sensors (Basel, Switzerland) · 2025Article
- Comparative Analysis of Standing Postural Control and Perturbation-Induced Muscle Activity in Transtibial and Transfemoral Amputees.Journal of clinical medicine · 2025Article
- Compensation for balance disorders: analysis of this multifactorial process.European journal of translational myology · 2025Article
- Impact of Long-Term Home and Community Use of a Lower Limb Sensory Neuroprosthesis.Research square · 2025Article
- Postural control and trunk muscle activation in transtibial amputees: A pilot electromyographic study.PloS one · 2025Observational
- Corticomuscular coherence during upright standing in unilateral transfemoral amputees.Brain communications · 2025Article
- Effect of different inner pressures of air insoles and walking durations on plantar pressure time integral.Scientific reports · 2024Article
- Resting state neurophysiology of agonist-antagonist myoneural interface in persons with transtibial amputation.Scientific reports · 2024Article
- Postural control imbalance in individuals with a minor lower extremity amputation: a scoping review protocol.F1000Research · 2024Article
- Altered local and remote functional connectivity in mild Alzheimer's disease patients with sleep disturbances.Frontiers in aging neuroscience · 2023Article
- Clinical measures of balance and gait cannot differentiate somatosensory impairments in people with lower-limb amputation.Gait & posture · 2023Article
- Neuromuscular adaptations after osseointegration of a bone-anchored prosthesis in a unilateral transfemoral amputee - a case study.Annals of medicine · 2023Observational
- Use of a Single Wearable Sensor to Evaluate the Effects of Gait and Pelvis Asymmetries on the Components of the Timed Up and Go Test, in Persons with Unilateral Lower Limb Amputation.Sensors (Basel, Switzerland) · 2021Article
- Postural Control Strategies and Balance-Related Factors in Individuals with Traumatic Transtibial Amputations.Sensors (Basel, Switzerland) · 2021Article
- Inter-limb coupling in individuals with transtibial amputation during bilateral stance is direction dependent.Human movement science · 2021Article
- Neural interfacing architecture enables enhanced motor control and residual limb functionality postamputation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Influence of Augmented Visual Feedback on Balance Control in Unilateral Transfemoral Amputees.Frontiers in neuroscience · 2021Article
- Editorial: Wearable and Implantable Technologies in the Rehabilitation of Patients With Sensory Impairments.Frontiers in neuroscience · 2021Article
- Lower-Limb Amputees Adjust Quiet Stance in Response to Manipulations of Plantar Sensation.Frontiers in neuroscience · 2021Article
- Agonist-antagonist myoneural interface amputation preserves proprioceptive sensorimotor neurophysiology in lower limbs.Science translational medicine · 2020Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFollowing an amputation, the human postural control system develops neuromuscular adaptations to regain an effective postural control. We investigated the compensatory mechanisms behind these adaptations and how sensorimotor integration is affected after a lower-limb transfemoral amputation.
methodsCenter of pressure (CoP) data of 12 unilateral transfemoral amputees and 12 age-matched able-bodied subjects were recorded during quiet standing with eyes open (EO) and closed (EC). CoP adjustments under each leg were recorded to study their contribution to posture control. The spatial structure of the CoP displacements was characterized by measuring the mean distance, the mean velocity of the CoP adjustments, and the sway area. The Entropic Half-Life (EnHL) quantifies the temporal structure of the CoP adjustments and was used to infer disrupted sensory feedback loops in amputees. We expanded the analysis with measures of weight-bearing imbalance and asymmetry, and with two standardized balance assessments, the Berg Balance Scale (BBS) and Timed Up-and-Go (TUG).
resultsThere was no difference in the EnHL values of amputees and controls when combining the contributions of both limbs (p = 0.754). However, amputees presented significant differences between the EnHL values of the intact and prosthetic limb (p < 0.001). Suppressing vision reduced the EnHL values of the intact (p = 0.001) and both legs (p = 0.028), but not in controls. Vision feedback in amputees also had a significant effect (increase) on the mean CoP distance (p < 0.001), CoP velocity (p < 0.001) and sway area (p = 0.007). Amputees presented an asymmetrical stance. The EnHL values of the intact limb in amputees were positively correlated to the BBS scores (EO: ρ = 0.43, EC: ρ = 0.44) and negatively correlated to the TUG times (EO: ρ = - 0.59, EC: ρ = - 0.69).
conclusionThese results suggest that besides the asymmetry in load distribution, there exist neuromuscular adaptations after an amputation, possibly related to the loss of sensory feedback and an altered sensorimotor integration. The EnHL values suggest that the somatosensory system predominates in the control of the intact leg. Further, suppressing the visual system caused instability in amputees, but had a minimal impact on the CoP dynamics of controls. These findings points toward the importance of providing somatosensory feedback in lower-limb prosthesis to reestablish a normal postural control.
trial registrationDRKS00015254 , registered on September 20th, 2018.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.