Evidence map›Paper›PMID 31521168›Full record

ReviewLipids in health and disease2019

New insights into different adipokines in linking the pathophysiology of obesity and psoriasis.

Yi Kong, Suhan Zhang, Ruifang Wu, Xin Su, Daoquan Peng, Ming Zhao, Yuwen Su

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Lipids in health and disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Signaling pathways and targeted therapies for psoriasis.Signal transduction and targeted therapy · 2023
    Review
  9. Review
  10. Review
  11. Potential Therapeutic Value of the STING Inhibitors.Molecules (Basel, Switzerland) · 2023
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Exploring the Links between Obesity and Psoriasis: A Comprehensive Review.International journal of molecular sciences · 2022
    Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yi KongDepartment of Dermatology, Hunan Key Laboratory of Medical Epigenomics, the Second Xiangya Hospital of Central South University, 139 Renmin Middle Road, Changsha, 410011, Hunan, China.
Suhan ZhangDepartment of Dermatology, Hunan Key Laboratory of Medical Epigenomics, the Second Xiangya Hospital of Central South University, 139 Renmin Middle Road, Changsha, 410011, Hunan, China.
Ruifang WuDepartment of Dermatology, Hunan Key Laboratory of Medical Epigenomics, the Second Xiangya Hospital of Central South University, 139 Renmin Middle Road, Changsha, 410011, Hunan, China.
Xin SuDepartment of Cardiovascular Medicine, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Daoquan PengDepartment of Cardiovascular Medicine, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Ming ZhaoDepartment of Dermatology, Hunan Key Laboratory of Medical Epigenomics, the Second Xiangya Hospital of Central South University, 139 Renmin Middle Road, Changsha, 410011, Hunan, China. zhaoming307@csu.edu.cn.
Yuwen SuDepartment of Dermatology, Hunan Key Laboratory of Medical Epigenomics, the Second Xiangya Hospital of Central South University, 139 Renmin Middle Road, Changsha, 410011, Hunan, China. suyuwen1963@csu.edu.cn.

Funding

National Natural Science Foundation of China 81872534National Natural Science Foundation of China 81874243
6 · The paper itself

Abstract

Psoriasis is a chronic, systemic, hyper-proliferative immune-mediated inflammatory skin disease. The results of epidemiological investigations have shown that psoriasis affects around 2% of the general population worldwide, and the total number of psoriasis patients is more than 6 million in China. Apart from the skin manifestations, psoriasis has been verified to associate with several metabolic comorbidities, such as insulin resistance, diabetes and obesity. However, the underlying mechanism is still not elucidated. Adipocytes, considered as the active endocrine cells, are dysfunctional in obesity which displays increased synthesis and secretion of adipokines with other modified metabolic properties. Currently, growing evidence has pointed to the central role of adipokines in adipose tissue and the immune system, providing new insights into the effect of adipokines in linking the pathophysiology of obesity and psoriasis. In this review, we summarize the current understanding of the pathological role of adipokines and the potential mechanisms whereby different adipokines link obesity and psoriasis. Furthermore, we also provide evidence which identifies a potential therapeutic target aiming at adipokines for the management of these two diseases.

Indexed as

AdipocytesAdiponectinAdipose TissueCytokinesGene Expression RegulationGPI-Linked ProteinsHumansImmune SystemImmunologic FactorsInterleukin-1betaInterleukin-6Interleukin-6 InhibitorsLectinsLeptinMolecular Targeted TherapyObesityAdiponectinCytokinesGPI-Linked ProteinsIL1B protein, humanIL6 protein, humanImmunologic FactorsInterleukin-1betaInterleukin-6Interleukin-6 InhibitorsITLN1 protein, humanLectinsLeptinTumor Necrosis Factor-alphaAdipokineObesityPathophysiologyPsoriasisTreatment

Identifiers

PMID31521168
PMCPMC6745073

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.