Evidence map›Paper›PMID 31521162›Full record

ArticleBMC complementary and alternative medicine2019

Phytochemical, in-vitro biological and chemo-preventive profiling of Arisaema jacquemontii Blume tuber extracts.

Saira Tabassum, Muhammad Zia, Esperanza J Carcahe de Blanco, Riffat Batool, Roohi Aslam, Sajid Hussain, Qamar Wali, Muhammad Mudassar Gulzar

Abstract read
In one paragraph

Article in BMC complementary and alternative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Saira TabassumNUTECH School of Applied Sciences and Humanities, National University of Technology (NUTECH), Islamabad, Pakistan. sairatabassum@nutech.edu.pk.
Muhammad ZiaDepartment of Biotechnology, Quaid-I-Azam University, Islamabad, 45320, Pakistan.
Esperanza J Carcahe de BlancoDivision of Pharmacy Practice Science and Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
Riffat BatoolDepartment of Biotechnology, Quaid-I-Azam University, Islamabad, 45320, Pakistan.
Roohi AslamNUTECH School of Applied Sciences and Humanities, National University of Technology (NUTECH), Islamabad, Pakistan.
Sajid HussainNUTECH School of Applied Sciences and Humanities, National University of Technology (NUTECH), Islamabad, Pakistan.
Qamar WaliNUTECH School of Applied Sciences and Humanities, National University of Technology (NUTECH), Islamabad, Pakistan.
Muhammad Mudassar GulzarNUTECH School of Applied Sciences and Humanities, National University of Technology (NUTECH), Islamabad, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundArisaema jacquemontii is traditionally used in treatment of different diseases. In this study, phytochemical, in vitro biological and chemo-preventive screening of A. jacquemontii was carried out to explore its pharmacological potential.

methodsThe dried tuber of A. jacquemontii was extracted in 11 organic solvent mixture of different polarity. The extracts were screened for phytochemical assays (phenolics and flavonoids), antioxidants potential (free radical scavenging activity, total antioxidant activity, reducing power), biological activities (antibacterial, antifungal, cytotoxic, antileishmanial, protein kinase inhibition), and chemopreventive activities using different cell lines through standard protocols.

resultsSignificant amount phenolic contents were determined in EtOH and MeOH extracts (210.3 ± 3.05 and 193.2 ± 3.15 μg GAE/mg, respectively). Maximum flavonoid content was determined in MeOH extract (22.4 ± 4.04 μg QE/mg). Noteworthy, DPPH scavenging activity was also recorded for MeOH extract (87.66%) followed by MeOH+EtOAc extract (85.11%). Considerable antioxidant capacity (7.8 ± 0.12 μg AAE/mg) and reducing power (3.1 ± 0.15 μg AAE/mg) was observed in extract of MeOH. The LC

conclusionThe study concludes that Arisaema jacquemontii bears significant phytochemical activity and pharmacological activities, this plant can be further explored for isolation of active component against a number of aliments.

Indexed as

AnimalsAnti-Infective AgentsArisaemaArtemiaBacteriaFungiPhytochemicalsPlant ExtractsPlant TubersAnti-Infective AgentsPhytochemicalsPlant ExtractsAntimicrobialAntioxidant activitiesNF-kB pathwayPhenolic and flavonoid contentSRB cytotoxic assay

Identifiers

PMID31521162
PMCPMC6744708

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.