ArticleBMC immunology2019
Biological variation of immunological blood biomarkers in healthy individuals and quality goals for biomarker tests.
Article in BMC immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05174624 (The Healthy Human Global Project - Hong Kong), which is not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Healthy Human Global Project - Hong Kong: A Community-based Cross-sectional Study on Genetic and Environmental Determinants of Immune Phenotype Variance in a Healthy Asian Population - Establishing a Path Towards Personalized Medicine
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neonatal Encephalopathy biomarkers: outcome prediction from blood samples: systematic review and meta-analysis.Pediatric research · 2026Pooled it
- A systematic review of the latest progress of drug resistance and clinical application of immunotherapy in renal cell carcinoma in the past five years based on bibliometrics.Human vaccines & immunotherapeutics · 2025Pooled it
- Probiotics, Anticipation Stress, and the Acute Immune Response to Night Shift.Frontiers in immunology · 2020Trial
- A Bayesian Modeling Approach to Optimize Longitudinal Biomarker Sampling Schedules Using Hormonal Data.American journal of human biology : the official journal of the Human Biology Council · 2026Article
- Association of Circulating C-C Motif Chemokine Ligand 4 to Disease Severity and Clinical Outcomes in Sepsis: A Prospective Observational Study.Biomedicines · 2026Article
- Longitudinal changes in the phenotypic profile of circulating extracellular vesicles in healthy individuals.Frontiers in cell and developmental biology · 2026Article
- Why is Biomarker Assay Validation Different from that of Pharmacokinetic Assays?The AAPS journal · 2025Article
- Comparison of passive ultrasonic and sonically activated irrigation methods: an investigation based on PGE2, NO and IL-6 levels.BMC oral health · 2025Article
- Microvascular immunity is organ-specific and remodeled after kidney injury in mice.Nature communications · 2025Article
- Comprehensive Phenotyping of Extracellular Vesicles in Plasma of Healthy Humans - Insights Into Cellular Origin and Biological Variation.Journal of extracellular vesicles · 2025Article
- A global metric of immune health.Nature medicine · 2024Article
- Review
- The Impact of Whole-Body Cryotherapy on Endothelium Parameters in Patients with Ankylosing Spondylitis.Antioxidants (Basel, Switzerland) · 2023Article
- IL-6 signaling in acute exercise and chronic training: Potential consequences for health and athletic performance.Scandinavian journal of medicine & science in sports · 2023Review
- Biomarkers or biotargets? Using competition to lure cancer cells into evolutionary traps.Evolution, medicine, and public health · 2023Article
- Dynamics of methylated cell-free DNA in the urine of non-small cell lung cancer patients.Epigenetics · 2022Article
- Reference Interval for the Axis-Shield Clinical Chemistry Heparin-Binding Protein Assay.Diagnostics (Basel, Switzerland) · 2022Article
- Comparison of IL-6 measurement methods with a special emphasis on COVID-19 patients according to equipment and sample type.Journal of clinical laboratory analysis · 2022Article
- Human disease biomarker panels through systems biology.Biophysical reviews · 2021Review
- Inflammation response and liver stiffness: predictive model of regression of hepatic stiffness after sustained virological response in cirrhotics patients with chronic hepatitis C.Clinical and experimental medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundCytokines, chemokines, adipocytokines, soluble cell receptors, and immune activation markers play an important role in immune responsiveness and can provide prognostic value since they reflect underlying conditions and disease states. This study was undertaken to investigate the components of biological variation for various laboratory tests of blood immunological biomarkers.
resultsEstimates of intra-individual coefficient of variation (CV
conclusionThe biological variations of biomarkers have important monitoring value for longitudinal investigation and are essential for quality specification of tests that are performed in the laboratory. The CV
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.