Evidence map›Paper›PMID 31521013›Full record

ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2019

Comparison of phenotypic and genotypic diagnosis of acute human bocavirus 1 infection in children.

Nicola Isabelle Kols, Heli Aatola, Ville Peltola, Man Xu, Zaiga Nora-Krukle, Klaus Hedman, Aurelija Zvirbliene, Hanna Toivola, Tytti Vuorinen, Juha M Koskinen and 4 more

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 5 countries.

Nicola Isabelle KolsDepartment of Medical Microbiology, Clinic of Laboratory Medicine, St. Olavs Hospital HF, Trondheim University Hospital, 7006, Trondheim, Norway; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, 7491, Trondheim, Norway. Electronic address: nicola.isabelle.kols@stolav.no.
Heli AatolaArcDia International Oy Ltd, 20521, Turku, Finland.
Ville PeltolaDepartment of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, 20521, Turku, Finland.
Man XuDepartment of Virology, University of Helsinki, and Helsinki University Hospital, 00290, Helsinki, Finland.
Zaiga Nora-KrukleDepartment of Virology, University of Helsinki, and Helsinki University Hospital, 00290, Helsinki, Finland; Institute of Microbiology and Virology, Riga Stradins University, LV-1067, Riga, Latvia.
Klaus HedmanDepartment of Virology, University of Helsinki, and Helsinki University Hospital, 00290, Helsinki, Finland; Helsinki University Hospital, 00029, Helsinki, Finland.
Aurelija ZvirblieneDepartment of Immunology and Cell Biology, Institute of Biotechnology, Life Sciences Center, Vilnius University, LT-10223, Vilnius, Lithuania.
Hanna ToivolaArcDia International Oy Ltd, 20521, Turku, Finland.
Tytti VuorinenDepartment of Clinical Microbiology, Turku University Hospital and Department of Virology, University of Turku, 20521, Turku, Finland.
Juha M KoskinenArcDia International Oy Ltd, 20521, Turku, Finland.
Andrea H L BruningDepartment of Pediatric Infectious Diseases, Emma Children's Hospital, Academic Medical Center, 1105, Amsterdam, the Netherlands.
Andreas ChristensenDepartment of Medical Microbiology, Clinic of Laboratory Medicine, St. Olavs Hospital HF, Trondheim University Hospital, 7006, Trondheim, Norway; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, 7491, Trondheim, Norway.
Maria Söderlund-VenermoDepartment of Virology, University of Helsinki, and Helsinki University Hospital, 00290, Helsinki, Finland.
Janne O KoskinenArcDia International Oy Ltd, 20521, Turku, Finland.
University of Helsinki · FINorwegian University of Science and Technology · NOUniversity of Turku · FIAmsterdam UMC Location University of Amsterdam · NLVilnius University · LT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiagnosis of human bocavirus 1 (HBoV1) has been based on qualitative PCRs detecting HBoV1 DNA or detection of HBoV1 mRNA.

objectiveThis study aims to assess whether a rapid and automated HBoV1 antigen test is suitable for diagnosis of acute HBoV1 infection. STUDY

designHBoV1 antigen detection has been compared with quantitative HBoV1 DNA PCR and HBoV1 mRNA RT-PCR. RESULTS AND

conclusionWe conclude that HBoV1 antigen detection has higher clinical specificity and positive predictive value than HBoV1 DNA qualitative PCRs, yet a lower sensitivity than HBoV1 mRNA detection. Additionally, HBoV1 antigen detection is beneficial in its rapidity and availability as a point-of-care test.

Indexed as

Antigens, ViralAutomationChildDNA, ViralFemaleGenotypeHuman bocavirusHumansMaleParvoviridae InfectionsPhenotypePoint-of-Care SystemsRespiratory Tract InfectionsReverse Transcriptase Polymerase Chain ReactionRNA, MessengerRNA, ViralAntigens, ViralDNA, ViralRNA, MessengerRNA, ViralDiagnosisHuman bocavirus 1ParvovirusPediatric infectionPolymerase chain reactionRapid antigen detection assayRespiratory tract infection

Identifiers

PMID31521013
PMCPMC7106360
OpenAlexW2971361841

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.