ArticleClinical oral implants research2019
A preclinical model links osseo-densification due to misfit and osseo-destruction due to stress/strain.
Article in Clinical oral implants research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Preclinical Rat Models in Oral Implant Dentistry: A Scoping Review of Study Design and Experimental Practices.Dentistry journal · 2026Review
- Primary Stability of Implants Inserted Using Different Osseodensification Systems in Low-Density Bone: An In Vitro Study.Dentistry journal · 2026Article
- Preclinical Performance of a Novel Dental Implant Design Reducing Mechanical Stress in Cortical Bone.Journal of functional biomaterials · 2025Article
- Influence of buccal and palatal bone thickness on post-surgical marginal bone changes around implants placed in posterior maxilla: a multi-centre prospective study.BMC oral health · 2023Article
- Influence of apico-coronal positioning of tissue-level implants on marginal bone stability during supracrestal tissue height establishment: A multi-center prospective study.Clinical implant dentistry and related research · 2022Article
- Bone formation around unstable implants is enhanced by a WNT protein therapeutic in a preclinical in vivo model.Clinical oral implants research · 2020Article
- Comparison of Primary Stability of Implants Installed by Two Different Methods in D3 and D4 Bone Types: AnJournal of International Society of Preventive & Community DentistryArticle
- Implant Primary and Secondary Stability after Site Preparation with Electromagnetic Osteotomes or Osseodensification Burs: a Randomized Controlled Trial with Split-Mouth Design.Journal of oral & maxillofacial researchArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectivePrimary stability is a prerequisite for implant osseointegration. Some degree of misfit between an implant and its osteotomy is required to ensure primary stability, and this is typically achieved by undersizing an implant osteotomy. In this preclinical study, we aimed at understanding the relationship between misfit, insertion torque, implant stability, and their cumulative short- and longer-term effects on peri-implant bone. MATERIALS AND
methodsWe placed implants in maxillary extraction sites of a rat; in the control group, these implants had minimal misfit while those in the test group had a high degree of misfit and therefore osseo-densified the peri-implant bone.
resultsCompared to controls, the misfit-induced stresses produced by osseo-densification led to micro-fractures in the peri-implant bone and an extensive zone of dying osteocytes. High interfacial pressures produced a pro-resorptive environment as shown by tartrate-resistant acid phosphatase activity and cathepsin K immunostaining (IHC). The lack of alkaline phosphatase activity and collagen I IHC supported the absence of new bone formation. Collectively, micro-computed tomography imaging, quantification of bone-implant contact (BIC), vimentin, and IL1-β IHCs demonstrated that implant failure occurred soon afterward, which presented as a crater-like lesion filled with fibrous, inflamed granulation tissue around the test implants.
conclusionBy controlling every other risk indicator, we confirmed how excessive osseo-densification can lead directly to osseo-destruction.
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Registered trials
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