Evidence map›Paper›PMID 31520451›Full record

ArticleThe FEBS journal2020

Multisite rate control analysis identifies ribosomal scanning as the sole high-capacity/low-flux-control step in mRNA translation.

Helena Firczuk, James Teahan, Pedro Mendes, John E G McCarthy

Open access · hybridAbstract read
In one paragraph

Article in The FEBS journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Helena FirczukWarwick Integrative Synthetic Biology Centre [WISB] and School of Life Sciences, University of Warwick, Coventry, UK.
James TeahanWarwick Integrative Synthetic Biology Centre [WISB] and School of Life Sciences, University of Warwick, Coventry, UK.
Pedro MendesCenter for Quantitative Medicine, UConn Health, Farmington, CT, USA.
John E G McCarthyWarwick Integrative Synthetic Biology Centre [WISB] and School of Life Sciences, University of Warwick, Coventry, UK.ORCID 0000-0001-5980-8432
University of Warwick · GBQuantitative BioSciences · US

Funding

COPASI software for modeling and simulation of biochemical networksR01GM080219 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI HOOPS, STEFAN, MENDES, PEDRO · 2007 to 2019
$5.4M
Biotechnology & Biological Sciences Research Council BB/1008349/1Biotechnology & Biological Sciences Research Council BB/1020535/1Biotechnology and Biological Sciences Research Council BB/M017982/1NIGMS NIH HHS R01 GM080219
6 · The paper itself

Abstract

Control of complex intracellular pathways such as protein synthesis is critical to organism survival, but is poorly understood. Translation of a reading frame in eukaryotic mRNA is preceded by a scanning process in which a subset of translation factors helps guide ribosomes to the start codon. Here, we perform comparative analysis of the control status of this scanning step that sits between recruitment of the small ribosomal subunit to the m

Indexed as

Computational BiologyModels, TheoreticalPeptide Chain Initiation, TranslationalProtein BiosynthesisRibosomesRNA, MessengerRNA, Messengerpolypeptide initiationprotein synthesisrate controlribosomal scanningyeast

Identifiers

PMID31520451
PMCPMC7054134
OpenAlexW2972863767

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.