ReviewAdvances in experimental medicine and biology2019
Drosophila as a Model for Tumor-Induced Organ Wasting.
Review in Advances in experimental medicine and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Article
- Drosophila Intestine as a Model to Study Tumors.Advances in experimental medicine and biology · 2025Review
- Using Drosophila to uncover the role of organismal physiology and the tumor microenvironment in cancer.Trends in cancer · 2024Review
- The roles of the native cell differentiation program aberrantly recapitulated in Drosophila intestinal tumors.Cell reports · 2023Article
- Article
- Article
- Tumor-Induced Cardiac Dysfunction: A Potential Role of ROS.Antioxidants (Basel, Switzerland) · 2021Article
- Review
- Metabolic reprogramming in cancer: mechanistic insights from Drosophila.Disease models & mechanisms · 2021Review
- Tumors overcome the action of the wasting factor ImpL2 by locally elevating Wnt/Wingless.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Misshapen Disruption Cooperates withCells · 2021Article
- Tumor Allotransplantation in Drosophila melanogaster with a Programmable Auto-Nanoliter Injector.Journal of visualized experiments : JoVE · 2021Article
- Origin and Development of the Adipose Tissue, a Key Organ in Physiology and Disease.Frontiers in cell and developmental biology · 2021Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In humans, cancer-associated cachexia is a complex syndrome that reduces the overall quality of life and survival of cancer patients, particularly for those undergoing chemotherapy. The most easily observable sign of cachexia is organ wasting, the dramatic loss of skeletal muscle and adipose tissue mass. Estimates suggest that 80% of patients in advanced stages of cancer show signs of the syndrome and about 20% of cancer patients die directly of cachexia. Because there is no treatment or drug available to ameliorate organ wasting induced by cancer, cachexia is a relevant clinical problem. However, it is unclear how cachexia is mediated, what factors drive interactions between tumors and host tissues, and which markers of cachexia might be used to allow early detection before the observable signs of organ wasting. In this chapter, we review the current mammalian models of cachexia and the need to use new models of study. We also explain recent developments in Drosophila as a model for studying organ wasting induced by tumors and how fly studies can help unravel important mechanisms that drive cachexia. In particular, we discuss what lessons have been learned from tumor models recently reported to induce systemic organ wasting in Drosophila.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.