Evidence map›Paper›PMID 31520338›Full record

ArticleJournal of the American Society for Mass Spectrometry2019

A Mechanistic Study of Protonated Aniline to Protonated Phenol Substitution Considering Tautomerization by Ion Mobility Mass Spectrometry and Tandem Mass Spectrometry.

Christopher Kune, Cédric Delvaux, Jean R N Haler, Loïc Quinton, Gauthier Eppe, Edwin De Pauw, Johann Far

Abstract read
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In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 16 citations in OpenAlex.

  1. Multi-Mycotoxin Quantification in Soy Protein Powders, Soymilk, Soybeans (Journal of agricultural and food chemistry · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Christopher KuneMOLSYS, Mass Spectrometry Laboratory, University of Liège, Quartier Agora, Allée du Six Aout 11, B-4000, Liège, Belgium. c.kune@uliege.be.ORCID http://orcid.org/0000-0002-3010-8173
Cédric DelvauxMOLSYS, Mass Spectrometry Laboratory, University of Liège, Quartier Agora, Allée du Six Aout 11, B-4000, Liège, Belgium.
Jean R N HalerMOLSYS, Mass Spectrometry Laboratory, University of Liège, Quartier Agora, Allée du Six Aout 11, B-4000, Liège, Belgium.
Loïc QuintonMOLSYS, Mass Spectrometry Laboratory, University of Liège, Quartier Agora, Allée du Six Aout 11, B-4000, Liège, Belgium.
Gauthier EppeMOLSYS, Mass Spectrometry Laboratory, University of Liège, Quartier Agora, Allée du Six Aout 11, B-4000, Liège, Belgium.
Edwin De PauwMOLSYS, Mass Spectrometry Laboratory, University of Liège, Quartier Agora, Allée du Six Aout 11, B-4000, Liège, Belgium.
Johann FarMOLSYS, Mass Spectrometry Laboratory, University of Liège, Quartier Agora, Allée du Six Aout 11, B-4000, Liège, Belgium.
University of Liège · BEFlorida International University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the use of ion mobility mass spectrometry (IMMS) and energy-resolved collisional activation to investigate gas-phase reactions of protonated aniline and protonated phenol. Protonated aniline prototropic tautomerization and nucleophilic substitution (SN1) to produce phenol with traces of water in the IMMS cell are reported. Tautomerization of protonated phenol and its ability to form protonated aniline in presence of ammonia in the gas phase are also observed. These results are supported by energy landscapes obtained from computational chemistry. These structure modifications in the IMMS cell affected the measured collision cross section (CCS). A thorough understanding of the gas-phase reactions occurring in IMMS appears mandatory before using the experimental CCS as a robust descriptor which is stated by the recent literature.

Indexed as

AnilineComputational chemistryGas-phase reactionIon mobilityMass spectrometryNucleophilic substitutionPhenolTautomerism

Identifiers

PMID31520338
OpenAlexW2972871891

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.