Evidence map›Paper›PMID 31520314›Full record

ArticleMolecular neurobiology2020

Calcium/Calmodulin-Dependent Kinase (CaMKII) Inhibition Protects Against Purkinje Cell Damage Following CA/CPR in Mice.

Nicholas E Chalmers, Joan Yonchek, Kathryn E Steklac, Matthew Ramsey, K Ulrich Bayer, Paco S Herson, Nidia Quillinan

Open access · greenAbstract read
In one paragraph

Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. The GHB analogue HOCPCA improves deficits in cognition and sensorimotor function after MCAO via CaMKIIα.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  4. Article
  5. Role of CaFrontiers in molecular neuroscience · 2022
    Review
  6. Review
  7. Article
  8. Article
  9. Effect of Shenfu Injection on Porcine Renal Function after Cardiopulmonary Resuscitation.Evidence-based complementary and alternative medicine : eCAM · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Nicholas E ChalmersNeuronal Injury Program, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Joan YonchekNeuronal Injury Program, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Kathryn E SteklacNeuronal Injury Program, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Matthew RamseyNeuronal Injury Program, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
K Ulrich BayerDepartment of Pharmacology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Paco S HersonNeuronal Injury Program, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Nidia QuillinanNeuronal Injury Program, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA. nidia.quillinan@ucdenver.edu.
University of Colorado Anschutz Medical Campus · US

Funding

CaMKII in global cerebral ischemiaR01NS080851 · NINDS · UNIVERSITY OF COLORADO DENVER · PI BAYER, K. ULRICH, HERSON, PACO S · 2013 to 2017
$2.1M
Differential mechanisms and consequences of Purkinje cell loss in an adult and pediatric model of global cerebral ischemiaK01NS086969 · NINDS · UNIVERSITY OF COLORADO DENVER · PI QUILLINAN, NIDIA · 2015 to 2017
$673k
NINDS NIH HHS K01 NS086969NINDS NIH HHS R01 NS080851
6 · The paper itself

Abstract

Ischemic brain damage is triggered by glutamate excitotoxicity resulting in neuronal cell death. Previous research has demonstrated that N-methly-D-aspartate (NMDA) receptor activation triggers downstream calcium-dependent signaling pathways, specifically Ca

Indexed as

AnimalsCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium SignalingCalmodulinMaleMice, Inbred C57BLNeuronsProtective AgentsPurkinje CellsCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2CalmodulinProtective AgentsCalcium/calmodulin-dependent protein kinaseCerebellumExcitotoxicityIschemiaNeuroprotection

Identifiers

PMID31520314
PMCPMC6980452
OpenAlexW2973156172

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.