ReviewHeart failure reviews2020
Loop diuretic resistance complicating acute heart failure.
Review in Heart failure reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- External validation of the BAN-ADHF diuretic-resistance score in the DAPA-RESIST clinical trial.British journal of clinical pharmacology · 2026Trial
- Outpatient loop diuretic use and the effect of natriuresis-guided diuretic therapy: A prespecified sub-analysis of the PUSH-AHF study.European journal of heart failure · 2025Trial
- Dapagliflozin vs. metolazone in heart failure resistant to loop diuretics.European heart journal · 2023Trial
- Trial
- A Step Forward Toward Precision Diuretic Management in Patients with Acute Decompensated Heart Failure and Diuretic Resistance.Journal of the American Society of Nephrology : JASN · 2026Article
- Loop Diuretic Dose Intensification versus Adjuvant Thiazide for Diuretic Resistance in Acute Heart Failure: Mechanistic Randomized Controlled Trial.Journal of the American Society of Nephrology : JASN · 2026Article
- Hyponatraemia in heart failure: a mechanistic approach to contemporary management.Heart failure reviews · 2026Review
- Mineralocorticoid Receptor Antagonist Use in Contemporary Heart Failure Care.Cardiac failure review · 2026Review
- Decongestion in heart failure: medical and device therapies.Nature reviews. Cardiology · 2025Review
- Diuretic resistance in cardiorenal syndrome: mechanisms, monitoring and phenotype-tailored management.Frontiers in cardiovascular medicine · 2025Review
- Development of a Novel Intraperitoneal Icodextrin/Dextrose Solution for Enhanced Sodium Removal.Kidney medicine · 2025Article
- Comparative analysis of furosemide and torsemide efficacy in 24 hours of acute heart failure admission.Frontiers in pharmacology · 2025Article
- Integrating the BAN-ADHF diuretic resistance score into same day emergency care centres for heart failure management: a conceptual framework.Frontiers in cardiovascular medicine · 2025Article
- Thoracic Fluid Content as an Indicator of High Intravenous Diuretic Requirements in Hospitalized Patients with Decompensated Heart Failure.Journal of clinical medicine · 2024Article
- The Effect of Early Administration of Hypertonic Saline Solution İn Acute Decompensated Heart Failure.Arquivos brasileiros de cardiologia · 2024Article
- The Role of Sodium-Glucose Co-Transporter-2 Inhibitors on Diuretic Resistance in Heart Failure.International journal of molecular sciences · 2024Review
- Diuretic Combination Therapy in Acute Heart Failure: An Updated Review.Current pharmaceutical design · 2024Review
- Review
- Conduction System Pacing: Have We Finally Found the Holy Grail of Physiological Pacing?Heart international · 2023Review
- Impact of Loop Diuretic on Outcomes in Patients with Heart Failure and Reduced Ejection Fraction.Current heart failure reports · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute heart failure hospitalizations complicated by diuretic resistance are associated with worse outcomes. Yet, quantification of the frequency and accompanying risk from loop diuretic resistance is limited by the absence of a comprehensive definition with universal clinical application. Herein, we outline limitations of the current metrics used to identify and define diuretic resistance. We discuss the best available methods to identify and prognosticate outcomes in diuretic resistance. We propose a mechanism-based classification system of diuretic resistance by anatomical location as follows: pre-nephron resistance, pre-loop of Henle resistance, loop of Henle resistance, and post-loop of Henle resistance. Within this paradigm, we compare and contrast historical beliefs of resistance mechanisms with current literature specific to patients with heart failure. We recommend a treatment pathway to restore diuretic efficacy with a literature review of the various combination diuretic strategies and ongoing clinical trials that may impact current best practices.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.