Evidence map›Paper›PMID 31520220›Full record

ArticleArchives of virology2019

Human bocavirus infection in Belgian children with respiratory tract disease.

Vanessa Verbeke, Marijke Reynders, Katelijne Floré, Wouter Vandewal, Sara Debulpaep, Kate Sauer, Frederik Cardoen, Elizaveta Padalko

Abstract read
In one paragraph

Article in Archives of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Review
  7. Beyond respiratory syncytial virus and rhinovirus: The other viral respiratory bandits.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
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  15. Human bocavirus-1 infections in Australian children aged < 2 years: a birth cohort study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023
    Article
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vanessa VerbekeDepartment of Medical Microbiology, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium.
Marijke ReyndersAZ Sint-Jan Bruges, Ruddershove 10, 8000, Brugge, Belgium.
Katelijne FloréAZ Sint-Jan Bruges, Ruddershove 10, 8000, Brugge, Belgium.
Wouter VandewalAZ Sint-Lucas Bruges, Sint-Lucaslaan 29, 8310, Brugge, Belgium.
Sara DebulpaepDepartment of Pediatrics, Ghent University Hospital, Ghent, Belgium.
Kate SauerAZ Sint-Jan Bruges, Ruddershove 10, 8000, Brugge, Belgium.
Frederik CardoenAZ Sint-Lucas Bruges, Sint-Lucaslaan 29, 8310, Brugge, Belgium.
Elizaveta PadalkoDepartment of Medical Microbiology, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium. Elizaveta.Padalko@uzgent.be.ORCID http://orcid.org/0000-0002-8101-6957

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human bocavirus (HBoV) has been detected primarily in children with acute lower respiratory tract disease (LRTD), but its occurrence, clinical profile, and role as a causative agent of RTD are not clear. The aim of this study was to investigate the prevalence and the potential clinical relevance of HBoV. Using molecular tests, we tested 1352 nasopharyngeal samples obtained between October 1, 2017 and April 30, 2018 from children up to the age of 16 with RTD for the presence of HBoV DNA and 20 other respiratory pathogens at three different hospitals in Belgium. HBoV was detected in 77 children with a median age of 10.6 months. Consecutive samples were available for 15 HBoV-positive children and showed persistent HBoV positivity in four of them. Monoinfection was observed in six infants. Four of them were born prematurely and were infected during hospitalization at the neonatal intensive care unit (NICU). Only one of these six monoinfected children was diagnosed with recurrent wheezing due to HBoV. This child was carried to term and had a high viral load. Coinfections, most frequently with rhinovirus (52.1%) and adenovirus (49.3%), were observed in 72 patients. In seventeen of them in which HBoV was present at high viral load or higher viral load than its copathogens, bronchi(oli)tis (n = 8), recurrent wheezing (n = 8) or episodic wheezing (n = 1) were diagnosed. Our results suggest that HBoV infection at high viral load in infants is associated with wheezing (P = 0.013, Cramer's V = 0.613).

Indexed as

AdolescentBelgiumChildChild, PreschoolCross InfectionDNA, ViralFemaleHuman bocavirusHumansInfantInfant, NewbornIntensive Care Units, NeonatalMaleNasopharynxParvoviridae InfectionsPremature BirthDNA, Viral

Identifiers

PMID31520220
PMCPMC7087345

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.