Evidence map›Paper›PMID 31520153›Full record

ArticleNeuroradiology2019

Multifaceted structural magnetic resonance imaging findings in demented patients with pathologically confirmed TDP-43 proteinopathy.

Keita Sakurai, Satoru Morimoto, Takuya Oguri, Hiroyuki Yuasa, Yuto Uchida, Kentaro Yamada, Masahiro Muto, Yufuko Saito, Ikuko Aiba, Masaki Takao and 9 more

Abstract read
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In one paragraph

Article in Neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 13 institutions in 1 country.

Keita SakuraiDepartment of Radiology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan. ksak666@yahoo.co.jp.ORCID http://orcid.org/0000-0002-8849-7335
Satoru MorimotoDepartment of Physiology, School of Medicine, Keio University, Tokyo, Japan.
Takuya OguriDepartment of Neurology, Tosei General Hospital, Seto, Japan.
Hiroyuki YuasaDepartment of Neurology, Tosei General Hospital, Seto, Japan.
Yuto UchidaDepartment of Neurology, Toyokawa City Hospital, Toyokawa, Japan.
Kentaro YamadaDepartment of Neurology, Nagoya City East Medical Center, Nagoya, Japan.
Masahiro MutoDepartment of Radiology, Nagoya City East Medical Center, Nagoya, Japan.
Yufuko SaitoDepartment of Neurology, National Hospital Organization Higashi Nagoya National Hospital, Nagoya, Japan.
Ikuko AibaDepartment of Neurology, National Hospital Organization Higashi Nagoya National Hospital, Nagoya, Japan.
Masaki TakaoDepartment of Neurology and Cerebrovascular Medicine, Saitama Medical University International Medical Center, Hidaka, Japan.
Shohei InuiDepartment of Radiology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan.
Keiko ToyodaDepartment of Radiology, The Jikei University Daisan Hospital, Komae, Japan.
Asako YamamotoDepartment of Radiology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan.
Hidetsuna UtsunomiyaDepartment of Radiology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan.
Hiroshi ObaDepartment of Radiology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan.
Aya M TokumaruDepartment of Diagnostic Radiology, Tokyo Metropolitan Medical Center of Gerontology, Tokyo, Japan.
Motoo NakagawaDepartment of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Yoshio HashizumeChoju Medical Institute, Fukushimura Hospital, Toyohashi, Japan.
Mari YoshidaDepartment of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Japan.
Teikyo University · JPHigashi Nagoya National Hospital · JPNagoya Medical Center · JPTosei General Hospital · JPAichi Medical University · JPFukushimura Hospital · JPKeio University · JPNagoya City University · JPSaitama Medical University · JPThe Jikei University Hospital · JPThe University of Tokyo · JPTokyo Metropolitan Institute of Gerontology · JPToyokawa City Hospital · JP

Funding

Japanese Ministry of Education, Culture, Sports, Science and Technology Kakenhi Wakate B, 16K19839
6 · The paper itself

Abstract

This short report clarifies the heterogeneity of structural magnetic resonance imaging (MRI) findings in seven demented patients due to pathologically accumulated TAR DNA-binding protein-43 (TDP-43) protein using visual analyses including visual rating scales (i.e., global cortical atrophy and medial temporal atrophy scales). In addition to the well-known frontotemporal lobar atrophy, structural MRI has revealed multifaceted imaging findings including asymmetric atrophy of the frontoparietal lobe and cerebral peduncle, midbrain atrophy, and localized or diffuse white matter T2 hyperintensity. Understanding of these multifaceted neuroimaging findings is important for the precise antemortem diagnosis of TDP-43 proteinopathy.

Indexed as

AgedAtrophyFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesTDP-43 ProteinopathiesAtrophyFrontotemporal lobar degenerationMagnetic resonance imagingSignal changeTDP-43 proteinopathyVisual rating scale

Identifiers

PMID31520153
OpenAlexW2973202257

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.