Evidence map›Paper›PMID 31519927›Full record

ArticleScientific reports2019

Artificial neural network analysis of the oxygen saturation signal enables accurate diagnostics of sleep apnea.

Sami Nikkonen, Isaac O Afara, Timo Leppänen, Juha Töyräs

Erratum issuedAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Barriers of artificial intelligence implementation in the diagnosis of obstructive sleep apnea.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2022
    Review
  9. Pulse Oximetry: The Working Principle, Signal Formation, and Applications.Advances in experimental medicine and biology · 2022
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Sami NikkonenDepartment of Applied Physics, University of Eastern Finland, Kuopio, Finland. sami.nikkonen@kuh.fi.ORCID http://orcid.org/0000-0003-0615-4118
Isaac O AfaraDepartment of Applied Physics, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0001-7114-0439
Timo LeppänenDepartment of Applied Physics, University of Eastern Finland, Kuopio, Finland.
Juha TöyräsDepartment of Applied Physics, University of Eastern Finland, Kuopio, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The severity of obstructive sleep apnea (OSA) is classified using apnea-hypopnea index (AHI). Accurate determination of AHI currently requires manual analysis and complicated registration setup making it expensive and labor intensive. Partially for these reasons, OSA is a heavily underdiagnosed disease as only 7% of women and 18% of men suffering from OSA have diagnosis. To resolve these issues, we introduce an artificial neural network (ANN) that estimates AHI and oxygen desaturation index (ODI) using only the blood oxygen saturation signal (SpO2), recorded during ambulatory polygraphy, as an input. Therefore, hypopneas associated only with an arousal were not considered in this study. SpO2 signals from 1692 patients were used for training and 99 for validation. Two test sets were used consisting of 198 and 1959 patients. In the primary test set, the median absolute errors of ANN estimated AHI and ODI were 0.78 events/hour and 0.68 events/hour respectively. Based on the ANN estimated AHI and ODI, 90.9% and 94.4% of the test patients were classified into the correct OSA severity category. In conclusion, AHI and ODI can be reliably determined using neural network analysis of SpO2 signal. The developed method may enable a more affordable screening of OSA.

Indexed as

Neural Networks, ComputerSignal Processing, Computer-AssistedAdultAgedHumansMiddle AgedOximetryOxygenSleep Apnea, ObstructiveSleep Apnea SyndromesOxygen

Identifiers

PMID31519927
PMCPMC6744469

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.