Evidence map›Paper›PMID 31519888›Full record

ArticleNature communications2019

Structure of the thermo-sensitive TRP channel TRP1 from the alga Chlamydomonas reinhardtii.

Luke L McGoldrick, Appu K Singh, Lusine Demirkhanyan, Ting-Yu Lin, Ryan G Casner, Eleonora Zakharian, Alexander I Sobolevsky

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 35 citations in OpenAlex.

  1. Symmetry-driven gating of TRPM8 by PIPNature communications · 2026
    Article
  2. Article
  3. Article
  4. Thermotaxis in an apolar, non-neuronal animal.Journal of the Royal Society, Interface · 2023
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Origins of eukaryotic excitability.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021
    Review
  14. Article
  15. A folding reaction at the C-terminal domain drives temperature sensing in TRPM8 channels.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  16. Article
  17. Article
  18. Evolutionary Aspects of TRPMLs and TPCs.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Luke L McGoldrickDepartment of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, NY, 10032, USA.
Appu K SinghDepartment of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, NY, 10032, USA.
Lusine DemirkhanyanDepartment of Cancer Biology & Pharmacology, The University of Illinois College of Medicine at Peoria, One Illini Drive, Peoria, IL, 61605, USA.
Ting-Yu LinDepartment of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, NY, 10032, USA.ORCID http://orcid.org/0000-0001-7673-0673
Ryan G CasnerDepartment of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, NY, 10032, USA.ORCID http://orcid.org/0000-0002-2910-0908
Eleonora ZakharianDepartment of Cancer Biology & Pharmacology, The University of Illinois College of Medicine at Peoria, One Illini Drive, Peoria, IL, 61605, USA. zakharel@uic.edu.
Alexander I SobolevskyDepartment of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, NY, 10032, USA. as4005@cumc.columbia.edu.ORCID http://orcid.org/0000-0001-5181-8644
Columbia University · USUniversity of Illinois Urbana-Champaign · USColumbia University Irving Medical Center · US

Funding

TRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DE MARCO, ALEX · 2012 to 2021
$14.7M
TRAINING IN CELLULAR, MOLECULAR AND BIOPHYSICAL STUDIEST32GM008224 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI LIEM, RONALD K. · 1987 to 2021
$9.9M
Structure and Function of AMPA subtype ionotropic glutamate receptorsR01NS083660 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KURNIKOVA, MARIA G, SOBOLEVSKY, ALEXANDER · 2013 to 2022
$4.3M
Structure and function of Transient Receptor Potential ChannelsR01CA206573 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Alexander Sobolevsky · 2017 to 2026
$3.8M
Single-Particle Cryo-EM Characterization of AMPA Receptor Functional StatesR01NS107253 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Alexander Sobolevsky · 2018 to 2026
$3.5M
Structural and Functional Characterization of the Epithelial Calcium Channel TRPV6F31CA232391 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MCGOLDRICK, LUKE LAWRENCE · 2018 to 2018
$45k
NCI NIH HHS F31 CA232391NCI NIH HHS R01 CA206573NIGMS NIH HHS P41 GM103310NIGMS NIH HHS T32 GM008224NINDS NIH HHS R01 NS083660NINDS NIH HHS R01 NS107253
6 · The paper itself

Abstract

Algae produce the largest amount of oxygen on earth and are invaluable for human nutrition and biomedicine, as well as for the chemical industry, energy production and agriculture. The mechanisms by which algae can detect and respond to changes in their environments can rely on membrane receptors, including TRP ion channels. Here we present a 3.5-Å resolution cryo-EM structure of the transient receptor potential (TRP) channel crTRP1 from the alga Chlamydomonas reinhardtii that opens in response to increased temperature and is positively regulated by the membrane lipid PIP

Indexed as

Ankyrin RepeatChlamydomonas reinhardtiiCryoelectron MicroscopyHEK293 CellsHumansPlant ProteinsProtein Structure, SecondaryTransient Receptor Potential ChannelsPlant ProteinsTransient Receptor Potential Channels

Identifiers

PMID31519888
PMCPMC6744473
OpenAlexW2972395541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.