Evidence map›Paper›PMID 31519874›Full record

ArticleNature communications2019

Layer 4 of mouse neocortex differs in cell types and circuit organization between sensory areas.

Federico Scala, Dmitry Kobak, Shen Shan, Yves Bernaerts, Sophie Laturnus, Cathryn Rene Cadwell, Leonard Hartmanis, Emmanouil Froudarakis, Jesus Ramon Castro, Zheng Huan Tan and 6 more

Erratum issuedAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 111 papers.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

111 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Pronounced Neuroplasticity in the Primary Visual Cortex of the 13-Lined Ground Squirrel during Hibernation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Post-Critical Period Transcriptional and Physiological Adaptations of Primary Sensory Cortex after Sensory Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Federico ScalaCenter for Neuroscience and Artificial Intelligence, Baylor College of Medicine, Houston, TX, USA.
Dmitry KobakInstitute for Ophthalmic Research, University of Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0002-5639-7209
Shen ShanCenter for Neuroscience and Artificial Intelligence, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-9621-0314
Yves BernaertsInstitute for Ophthalmic Research, University of Tübingen, Tübingen, Germany.
Sophie LaturnusInstitute for Ophthalmic Research, University of Tübingen, Tübingen, Germany.
Cathryn Rene CadwellDepartment of Anatomic Pathology, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-1963-8285
Leonard HartmanisDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Emmanouil FroudarakisCenter for Neuroscience and Artificial Intelligence, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-3249-3845
Jesus Ramon CastroCenter for Neuroscience and Artificial Intelligence, Baylor College of Medicine, Houston, TX, USA.
Zheng Huan TanCenter for Neuroscience and Artificial Intelligence, Baylor College of Medicine, Houston, TX, USA.
Stelios PapadopoulosCenter for Neuroscience and Artificial Intelligence, Baylor College of Medicine, Houston, TX, USA.
Saumil Surendra PatelCenter for Neuroscience and Artificial Intelligence, Baylor College of Medicine, Houston, TX, USA.
Rickard SandbergDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-6473-1740
Philipp BerensInstitute for Ophthalmic Research, University of Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0002-0199-4727
Xiaolong JiangCenter for Neuroscience and Artificial Intelligence, Baylor College of Medicine, Houston, TX, USA. xiaolonj@bcm.edu.
Andreas Savas ToliasCenter for Neuroscience and Artificial Intelligence, Baylor College of Medicine, Houston, TX, USA. astolias@bcm.edu.ORCID http://orcid.org/0000-0002-4305-6376

Funding

Generation of novel cell type specific mouse genetic toolsU19MH114830 · NIMH · ALLEN INSTITUTE · PI ZENG, HONGKUI · 2017 to 2021
$64.7M
Deciphering the building blocks of hippocampal circuitsR01MH109556 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI SANDBERG, RICKARD, TOLIAS, ANDREAS · 2017 to 2021
$3.3M
Deciphering the building blocks of the macaque prefrontal cortical microcircuitR01MH120404 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI JIANG, XIAOLONG · 2019 to 2023
$2.0M
Deciphering the transcriptomic signatures, physiology, and connectivity of the specialized morphotypes in macaque insular cortexR01MH122169 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI JIANG, XIAOLONG · 2020 to 2024
$1.2M
NIMH NIH HHS R01 MH109556NIMH NIH HHS R01 MH120404NIMH NIH HHS R01 MH122169NIMH NIH HHS U19 MH114830
6 · The paper itself

Abstract

Layer 4 (L4) of mammalian neocortex plays a crucial role in cortical information processing, yet a complete census of its cell types and connectivity remains elusive. Using whole-cell recordings with morphological recovery, we identified one major excitatory and seven inhibitory types of neurons in L4 of adult mouse visual cortex (V1). Nearly all excitatory neurons were pyramidal and all somatostatin-positive (SOM

Indexed as

AnimalsElectrophysiologyFemaleInterneuronsMaleMiceNeocortexNeuronsSomatosensory CortexSomatostatinSomatostatin

Identifiers

PMID31519874
PMCPMC6744474

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.