Evidence map›Paper›PMID 31519862›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

Terminal Effector CD8 T Cells Defined by an IKZF2

Prossy Naluyima, Kerri G Lal, Margaret C Costanzo, Gustavo H Kijak, Veronica D Gonzalez, Kim Blom, Leigh Anne Eller, Matthew Creegan, Ting Hong, Dohoon Kim and 14 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 28 citations in OpenAlex.

  1. Trial
  2. BNT162b2 COVID-19 vaccination elicits the expansion of CD16The Journal of allergy and clinical immunology · 2025
    Article
  3. Article
  4. Unraveling clonal CD8 T cell expansion and identification of essential factors in γ-herpesvirus-induced lymphomagenesis.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. NK-like CD8Science immunology · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Gene editing to enhance the efficacy of cancer cell therapies.Molecular therapy : the journal of the American Society of Gene Therapy · 2021
    Review
  15. Self-Renewing Islet TCF1Journal of immunology (Baltimore, Md. : 1950) · 2021
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 9 institutions in 3 countries.

Prossy NaluyimaMakerere University Walter Reed Project, Kampala, Uganda.
Kerri G LalCenter for Infectious Medicine, Department of Medicine, Karolinska Institutet, 17177 Stockholm, Sweden.ORCID 0000-0002-8970-0198
Margaret C CostanzoU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Gustavo H KijakU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Veronica D GonzalezCenter for Infectious Medicine, Department of Medicine, Karolinska Institutet, 17177 Stockholm, Sweden.
Kim BlomCenter for Infectious Medicine, Department of Medicine, Karolinska Institutet, 17177 Stockholm, Sweden.
Leigh Anne EllerU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.ORCID 0000-0003-2043-1513
Matthew CreeganU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Ting HongDepartment of Global Health, University of Washington School of Public Health, Seattle, WA 98195.
Dohoon KimU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Thomas C QuinnLaboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852.ORCID 0000-0002-0404-1315
Niklas K BjörkströmCenter for Infectious Medicine, Department of Medicine, Karolinska Institutet, 17177 Stockholm, Sweden.ORCID 0000-0002-0967-076X
Hans-Gustaf LjunggrenCenter for Infectious Medicine, Department of Medicine, Karolinska Institutet, 17177 Stockholm, Sweden.ORCID 0000-0003-0908-7387
David SerwaddaRakai Health Sciences Program, Uganda Virus Research Institute, Entebbe, Uganda.
Elly T KatabiraFaculty of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
Nelson K SewankamboFaculty of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.ORCID 0000-0001-9362-053X
Ronald H GrayBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205.
Jared M BaetenDepartment of Global Health, University of Washington School of Public Health, Seattle, WA 98195.
Nelson L MichaelU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.ORCID 0000-0001-5882-5548
Fred Wabwire-MangenMakerere University Walter Reed Project, Kampala, Uganda.
Merlin L RobbU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.ORCID 0000-0003-3949-9649
Diane L BoltonU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Johan K SandbergCenter for Infectious Medicine, Department of Medicine, Karolinska Institutet, 17177 Stockholm, Sweden.ORCID 0000-0002-6275-0750
Michael A EllerU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910; meller@hivresearch.org.ORCID 0000-0003-3905-4877
Henry M. Jackson Foundation · USKarolinska Institutet · SEMakerere University · UGMakerere University Walter Reed Project · UGWashington State Department of Health · USJohns Hopkins University · USNational Institutes of Health · USRakai Health Sciences Program · UGWalter Reed Army Institute of Research · US

Funding

FILARIASIS REPOSITORY RESEARCH SERVICEN01AI002642 · NIAID · UNIVERSITY OF GEORGIA (UGA) · PI MC CALL, JOHN W · 1985 to 1987
–
NIAID NIH HHS Y01 AI002642
6 · The paper itself

Abstract

HIV-1 infection expands large populations of late-stage differentiated CD8 T cells that may persist long after viral escape from TCR recognition. In this study, we investigated whether such CD8 T cell populations can perform unconventional innate-like antiviral effector functions. Chronic untreated HIV-1 infection was associated with elevated numbers of CD45RA

Indexed as

AdolescentAdultAntibody-Dependent Cell CytotoxicityCD8-Positive T-LymphocytesCell DifferentiationCohort StudiesFemaleHIV-1HIV InfectionsHumansIkaros Transcription FactorMaleMiddle AgedProspective StudiesReceptors, IgGReceptors, Interleukin-7FCGR3A protein, humanIkaros Transcription FactorIKZF2 protein, humanReceptors, IgGReceptors, Interleukin-7

Identifiers

PMID31519862
PMCPMC6778306
OpenAlexW2972719678

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.