Evidence map›Paper›PMID 31519826›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Spatial Coupling Tunes NMDA Receptor Responses via Ca

Gary J Iacobucci, Gabriela K Popescu

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. The positive allosteric modulator GNE-9278 increases gating, conductance, and CaNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Salicylate- and Noise-induced Tinnitus. Different Mechanisms Producing the same Result? An Experimental Model.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Neuroprotective Effect of Valproic Acid on Salicylate-Induced Tinnitus.International journal of molecular sciences · 2021
    Article
  13. Review
  14. Article
  15. FRET-ting over Inactivation.Biophysical journal · 2020
    Article
  16. Distance-dependent regulation of NMDAR nanoscale organization along hippocampal neuron dendrites.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Gary J IacobucciDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, New York 14206 garyiaco@buffalo.edu.ORCID 0000-0001-7596-8380
Gabriela K PopescuDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, New York 14206.ORCID 0000-0003-4658-2002
Jacobs Institute · USUniversity at Buffalo, State University of New York · US

Funding

Probing allosteric surfaces of NMDA receptorsR01NS052669 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI POPESCU, GABRIELA K · 2006 to 2015
$3.4M
Molecular Physiology of NMDA ReceptorsR35NS132248 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Gabriela K Popescu · 2023 to 2026
$2.3M
Gating Mechanism of NMDA ReceptorsR01NS108750 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI POPESCU, GABRIELA K · 2019 to 2023
$1.5M
Permeation Mechanisms in NMDA receptorsR01NS097016 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI POPESCU, GABRIELA K · 2016 to 2019
$1.4M
Mechanical Activation of NMDA ReceptorsR21NS098385 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI POPESCU, GABRIELA K · 2016 to 2017
$439k
NINDS NIH HHS R01 NS052669NINDS NIH HHS R01 NS097016NINDS NIH HHS R01 NS108750NINDS NIH HHS R21 NS098385NINDS NIH HHS R35 NS132248
6 · The paper itself

Abstract

In the CNS, NMDA receptors generate large and highly regulated Ca

Indexed as

Action PotentialsCalcium SignalingAnimalsCalciumCalmodulinCells, CulturedDisks Large Homolog 4 ProteinFemaleHEK293 CellsHumansMaleNeuronsRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateCalciumCalmodulinDisks Large Homolog 4 ProteinDlg4 protein, ratReceptors, N-Methyl-D-Aspartatecalmodulinclusteringcooperative gatingNMDA receptorpatch-clampPSD-95

Identifiers

PMID31519826
PMCPMC6832682
OpenAlexW2973074739

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.