ArticleScience immunology2019
Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-T
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Article in Science immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
85 citing papers in PubMed, 116 citations in OpenAlex.
- Targeting T follicular helper cells for lifelong health.Nature reviews. Drug discovery · 2026Review
- Regulation of follicular helper T cell subset differentiation in health and disease.Journal of molecular medicine (Berlin, Germany) · 2026Review
- Vaccine Responses in Early Age.Vaccines · 2026Review
- Article
- IL-6-induced C/EBPα drives follicular regulatory T cell differentiation to regulate humoral immunity in mice.Nature communications · 2026Article
- An "old" cytokine's new trick: IL-1β in B cells and the germinal center.Function (Oxford, England) · 2026Review
- Disordered colonic microbiota as a potential contributor to inflammation in diarrheal Jinhua weaned piglets.Animal microbiome · 2026Article
- Lipid metabolism and inflammation as key drivers in preterm birth: A comprehensive analysis.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Article
- IRF4 Promotes Immune Evasion and Shapes the Tumor Microenvironment in Follicular Lymphoma.Blood cancer discovery · 2025Article
- T Cell Responses to Influenza Infections in Cattle.Viruses · 2025Review
- BLIMP1 negatively regulates IL-2 signaling in T cells.Science advances · 2025Article
- Coordinated Regulation of Extrafollicular B Cell Responses by IL-12 and IFNγ.Immunological reviews · 2025Review
- T cell-B cell interactions in human autoimmune diseases.Current opinion in immunology · 2025Review
- Revealing the role of regulatory b cells in cancer: development, function and treatment significance.Cancer immunology, immunotherapy : CII · 2025Review
- Clinical and Pathophysiological Tangles Between Allergy and Autoimmunity: Deconstructing an Old Dichotomic Paradigm.Clinical reviews in allergy & immunology · 2025Review
- A nucleoside-modified rabies mRNA vaccine induces long-lasting and comprehensive immune responses in mice and non-human primates.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- State of pneumococcal vaccine immunity.Human vaccines & immunotherapeutics · 2024Article
- The survival of B cells is compromised in kidney disease.Nature communications · 2024Article
- Cutting Edge: Low-dose Recombinant IL-2 Treatment Prevents Autoantibody Responses in Systemic Lupus Erythematosus via Regulatory T Cell-independent Depletion of T Follicular Helper Cells.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity.The Journal of experimental medicine · 2024Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Amber PapillionDivision of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0001-9227-8314
Michael D PowellVirginia Tech Carilion Research Institute, Roanoke, VA, USA.ORCID 0000-0003-2881-1334
Danielle A ChisolmDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Holly BachusDivision of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0003-4368-1734
Michael J FullerDivision of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-4494-4973
Amy S WeinmannDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Alejandro VillarinoMolecular Immunology and Inflammation Branch, NIAMS, NIH, Bethesda, MD, USA.ORCID 0000-0001-8068-2176
John J O'SheaMolecular Immunology and Inflammation Branch, NIAMS, NIH, Bethesda, MD, USA.ORCID 0000-0002-6456-9752
Beatriz LeónDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Kenneth J OestreichVirginia Tech Carilion Research Institute, Roanoke, VA, USA.ORCID 0000-0002-3004-072X
André Ballesteros-TatoDivision of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. andreballesterostato@uabmc.edu.ORCID 0000-0002-4833-593X
University of Alabama at Birmingham · USNational Institutes of Health · USCarilion Clinic · USVirginia–Maryland College of Veterinary Medicine · US
Funding
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OLAF KUTSCH · 1988 to 2026
$84.1MStat transcription factors in immunoregulation and autoimmune diseaseZIAAR041159 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI O'SHEA, JOHN · 2009 to 2025
$49.3MROS Modulation of Innate and Adaptive Immunity in RAP30AR048311 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MOUNTZ, JOHN D · 2001 to 2017
$9.5MMolecular characterization of the role for T-bet and Bcl-6 in immune cell metabolism and differentiationR01AI061061 · NIAID · UNIVERSITY OF WASHINGTON · PI WEINMANN, AMY SUSAN · 2004 to 2025
$7.0MRegulation of T cell responses to allergens and environmental microbesR01AI116584 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LUND, FRANCES E. · 2015 to 2024
$4.1MTraining Program in Rheumatic and Musculoskeletal Diseases ResearchT32AR069516 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI John D Mountz · 2016 to 2026
$2.6MIdentifying novel regulatory pathways underlying T helper 1 cell immune responsesR01AI134972 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI OESTREICH, KENNETH JOSEPH · 2018 to 2022
$1.9MRegulation of T-cell dependent B cell responses to influenzaR01AI110480 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BALLESTEROS-TATO, ANDRE · 2015 to 2019
$1.8MDeveloping and Improving Institutional Animal ResourcesG20RR022807 · NCRR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CARTNER, SAMUEL CORBIN · 2006 to 2006
$647kRegulation of T helper cell differentiation by integrated STAT and Ikaros zinc finger transcription factor mechanismsR56AI127800 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI OESTREICH, KENNETH JOSEPH · 2017 to 2017
$263kNCRR NIH HHS G20 RR022807NIAID NIH HHS P30 AI027767NIAID NIH HHS R01 AI061061NIAID NIH HHS R01 AI110480NIAID NIH HHS R01 AI116584NIAID NIH HHS R01 AI134972NIAID NIH HHS R56 AI127800NIAMS NIH HHS P30 AR048311NIAMS NIH HHS T32 AR069516
Abstract
Sustained T cell receptor (TCR) stimulation is required for maintaining germinal center T follicular helper (GC-T
Indexed as
AnimalsGerminal CenterInterleukin-2Interleukin-6MiceMice, Inbred C57BLMice, KnockoutReceptors, Antigen, T-CellSignal TransductionT-Lymphocytes, Helper-InducerInterleukin-2Interleukin-6Receptors, Antigen, T-Cell
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.