Evidence map›Paper›PMID 31519805›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2020

Dose-Dependent Growth Delay of Breast Cancer Xenografts in the Bone Marrow of Mice Treated with

Calvin N Leung, Brian S Canter, Didier Rajon, Tom A Bäck, J Christopher Fritton, Edouard I Azzam, Roger W Howell

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. The use of radiopharmaceuticals in targeted cancer therapy: a narrative review.International journal of physiology, pathophysiology and pharmacology · 2025
    Review
  5. MIRD Pamphlet No. 31: MIRDcell V4-Artificial Intelligence Tools to Formulate Optimized Radiopharmaceutical Cocktails for Therapy.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  6. Article
  7. Targeted Radium Alpha Therapy in the Era of Nanomedicine: In Vivo Results.International journal of molecular sciences · 2024
    Review
  8. Article
  9. Immunological effects of radiopharmaceutical therapy.Frontiers in nuclear medicine · 2024
    Review
  10. Review
  11. Review
  12. Targeted Alpha-Particle Therapy: A Review of Current Trials.International journal of molecular sciences · 2023
    Review
  13. Review
  14. Review
  15. Predicting response of micrometastases with MIRDcell V3: proof of principle withEuropean journal of nuclear medicine and molecular imaging · 2022
    Article
  16. MIRD Pamphlet No. 27: MIRDcell V3, a Revised Software Tool for Multicellular Dosimetry and Bioeffect Modeling.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  17. EnhancingJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Calvin N LeungDepartment of Radiology, New Jersey Medical School, Rutgers University, Newark, New Jersey.
Brian S CanterDepartment of Radiology, New Jersey Medical School, Rutgers University, Newark, New Jersey.
Didier RajonDepartment of Neurosurgery, University of Florida, Gainesville, Florida; and.
Tom A BäckDepartment of Radiation Physics, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
J Christopher FrittonDepartment of Orthopedics, New Jersey Medical School, Rutgers University, Newark, New Jersey.
Edouard I AzzamDepartment of Radiology, New Jersey Medical School, Rutgers University, Newark, New Jersey.
Roger W HowellDepartment of Radiology, New Jersey Medical School, Rutgers University, Newark, New Jersey rhowell@rutgers.edu.
Rutgers, The State University of New Jersey · USUniversity of Florida · USUniversity of Gothenburg · SE

Funding

Radiation induced bystander effects in radium-223 therapyR01CA198073 · NCI · RBHS-NEW JERSEY MEDICAL SCHOOL · PI AZZAM, EDOUARD I, HOWELL, ROGER W. · 2015 to 2018
$1.3M
NCI NIH HHS R01 CA198073
6 · The paper itself

Abstract

The role of radiation-induced bystander effects in radiation therapy remains unclear. With renewed interest in therapy with α-particle emitters, and their potential for sterilizing disseminated tumor cells (DTCs), it is critical to determine the contribution of bystander effects to the overall response so they can be leveraged for maximum clinical benefit.

Indexed as

Alpha ParticlesAnimalsBone MarrowBreast NeoplasmsBystander EffectCell Line, TumorCell ProliferationDose-Response Relationship, RadiationFemaleForkhead Transcription FactorsHumansImaging, Three-DimensionalMCF-7 CellsMiceMice, NudeMonte Carlo MethodForkhead Transcription FactorsRadiumRadium-223Whn protein223Rabreast cancerbystander effectirradiationα-particle

Identifiers

PMID31519805
PMCPMC6954456
OpenAlexW2972552227

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.