ArticleNeurology2019
White matter hyperintensity burden in patients with ischemic stroke treated with thrombectomy.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01062698 (The Contribution of Intra-arterial Thrombectomy in Acute Ischemic Stroke in Patients Treated With Intravenous Thrombolysis), which is not on this map. Cited by 31 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
5.7field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Contribution of Intra-arterial Thrombectomy in Acute Ischemic Stroke in Patients Treated With Intravenous Thrombolysis
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Leukoaraiosis severity and outcomes of endovascular thrombectomy for acute ischemic stroke: a systematic review and meta-analysis.European radiology · 2025Pooled it
- Impact of leukoaraiosis severity on the association of outcomes of mechanical thrombectomy for acute ischemic stroke: a systematic review and a meta-analysis.Journal of neurology · 2021Pooled it
- Small Vessel Disease Burden and Outcomes of Mechanical Thrombectomy in Ischemic Stroke: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Acute Treatment of Disabling and Nondisabling Minor Ischemic Stroke: Expert Guidance for Clinicians.Stroke · 2026Review
- Cerebral small vessel disease does not impair leptomeningeal collateral supply in large-vessel occlusion - Results from quantitative collateral mapping with MRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- Cerebral Small Vessel Disease and Infarct Growth in Acute Ischemic Stroke Treated with Intravenous Thrombolysis.Translational stroke research · 2025Article
- Brain Frailty on Neuroimaging Beyond Chronological Age Is Associated with Functional Outcome After Endovascular Thrombectomy in Patients with Anterior Large Vessel Occlusion.Therapeutics and clinical risk management · 2025Article
- Quantitative Analysis of White Matter Hyperintensities as a Predictor of 1-Year Risk for Ischemic Stroke Recurrence.Neurology and therapy · 2024Article
- Association Between the Timing of Atrial Fibrillation Detection and Functional Outcome Following Mechanical Thrombectomy.Journal of the American Heart Association · 2024Article
- Impact of White Matter Hyperintensity Volume on Prognosis After Mechanical Thrombectomy in Ischemic Stroke Patients.Stroke (Hoboken, N.J.) · 2024Article
- Article
- Cerebral Small Vessel Disease and Outcomes in Patients With Acute Ischemic Stroke Receiving Endovascular Treatment: A Systematic Review and Meta-Analysis.Stroke (Hoboken, N.J.) · 2023Article
- Leukoaraiosis severity is related to increased risk of early neurological deterioration in acute ischemic stroke: a retrospective observational study.Acta neurologica Belgica · 2023Observational
- A Nomogram for Predicting the Recurrence of Acute Non-Cardioembolic Ischemic Stroke: A Retrospective Hospital-Based Cohort Analysis.Brain sciences · 2023Article
- Association of White Matter Disease With Functional Recovery and 90-Day Outcome After EVT: Beyond Chronological Age.Stroke (Hoboken, N.J.) · 2023Article
- Cerebral small vessel disease and intracranial bleeding risk: Prognostic and practical significance.International journal of stroke : official journal of the International Stroke Society · 2023Review
- Impact of leukoaraiosis or blood pressure on clinical outcome, mortality and symptomatic intracerebral hemorrhage after mechanical thrombectomy in acute ischemic stroke.Scientific reports · 2022Article
- Cerebral Small Vessel Diseases and Outcomes for Acute Ischemic Stroke Patients after Endovascular Therapy.Journal of clinical medicine · 2022Article
- Elucidating the Role of Baseline Leukoaraiosis on Forecasting Clinical Outcome of Acute Ischemic Stroke Patients Undergoing Reperfusion Therapy.Neurology international · 2022Review
- Small vessel disease and collaterals in ischemic stroke patients treated with thrombectomy.Journal of neurology · 2022Article
Corrections and comments
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Authors and funding
19 authors at 1 institution in 2 countries.
Grégoire BoulouisFrom the Neuroradiology Department (G.B., W.B., J.B., L.L., D.T., C.R.-R., C.O., O.N.) and Neurology Department (G.T., P.S.), Paris Descartes University, INSERM U1266, DHU Neurovasculaire, Sainte-Anne Hospital, Paris; Neuroradiology Department (N.B., M.B.), Université de Lille (M.F., T.P., C.C., H.H.), Inserm U1171, Degenerative and Vascular Cognitive Disorders, CHU Lille, Department of Neurology, France; J. Philip Kistler Stroke Research Center (A.C., N.S.R.), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; and Neuroradiology Department (S.B.), Lorraine University, INSERM U1254 CHRU Nancy, France.ORCID 0000-0001-8422-9205
Nicolas BricoutFrom the Neuroradiology Department (G.B., W.B., J.B., L.L., D.T., C.R.-R., C.O., O.N.) and Neurology Department (G.T., P.S.), Paris Descartes University, INSERM U1266, DHU Neurovasculaire, Sainte-Anne Hospital, Paris; Neuroradiology Department (N.B., M.B.), Université de Lille (M.F., T.P., C.C., H.H.), Inserm U1171, Degenerative and Vascular Cognitive Disorders, CHU Lille, Department of Neurology, France; J. Philip Kistler Stroke Research Center (A.C., N.S.R.), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; and Neuroradiology Department (S.B.), Lorraine University, INSERM U1254 CHRU Nancy, France.ORCID 0000-0003-1469-3613
Wagih BenhassenFrom the Neuroradiology Department (G.B., W.B., J.B., L.L., D.T., C.R.-R., C.O., O.N.) and Neurology Department (G.T., P.S.), Paris Descartes University, INSERM U1266, DHU Neurovasculaire, Sainte-Anne Hospital, Paris; Neuroradiology Department (N.B., M.B.), Université de Lille (M.F., T.P., C.C., H.H.), Inserm U1171, Degenerative and Vascular Cognitive Disorders, CHU Lille, Department of Neurology, France; J. Philip Kistler Stroke Research Center (A.C., N.S.R.), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; and Neuroradiology Department (S.B.), Lorraine University, INSERM U1254 CHRU Nancy, France.ORCID 0000-0003-4858-3623
Marc FerrignoFrom the Neuroradiology Department (G.B., W.B., J.B., L.L., D.T., C.R.-R., C.O., O.N.) and Neurology Department (G.T., P.S.), Paris Descartes University, INSERM U1266, DHU Neurovasculaire, Sainte-Anne Hospital, Paris; Neuroradiology Department (N.B., M.B.), Université de Lille (M.F., T.P., C.C., H.H.), Inserm U1171, Degenerative and Vascular Cognitive Disorders, CHU Lille, Department of Neurology, France; J. Philip Kistler Stroke Research Center (A.C., N.S.R.), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; and Neuroradiology Department (S.B.), Lorraine University, INSERM U1254 CHRU Nancy, France.ORCID 0000-0001-6199-043X
Guillaume TurcFrom the Neuroradiology Department (G.B., W.B., J.B., L.L., D.T., C.R.-R., C.O., O.N.) and Neurology Department (G.T., P.S.), Paris Descartes University, INSERM U1266, DHU Neurovasculaire, Sainte-Anne Hospital, Paris; Neuroradiology Department (N.B., M.B.), Université de Lille (M.F., T.P., C.C., H.H.), Inserm U1171, Degenerative and Vascular Cognitive Disorders, CHU Lille, Department of Neurology, France; J. Philip Kistler Stroke Research Center (A.C., N.S.R.), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; and Neuroradiology Department (S.B.), Lorraine University, INSERM U1254 CHRU Nancy, France.ORCID 0000-0001-5059-4095
Martin BretznerFrom the Neuroradiology Department (G.B., W.B., J.B., L.L., D.T., C.R.-R., C.O., O.N.) and Neurology Department (G.T., P.S.), Paris Descartes University, INSERM U1266, DHU Neurovasculaire, Sainte-Anne Hospital, Paris; Neuroradiology Department (N.B., M.B.), Université de Lille (M.F., T.P., C.C., H.H.), Inserm U1171, Degenerative and Vascular Cognitive Disorders, CHU Lille, Department of Neurology, France; J. Philip Kistler Stroke Research Center (A.C., N.S.R.), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; and Neuroradiology Department (S.B.), Lorraine University, INSERM U1254 CHRU Nancy, France.ORCID 0000-0002-7594-4159
Joseph BenzakounFrom the Neuroradiology Department (G.B., W.B., J.B., L.L., D.T., C.R.-R., C.O., O.N.) and Neurology Department (G.T., P.S.), Paris Descartes University, INSERM U1266, DHU Neurovasculaire, Sainte-Anne Hospital, Paris; Neuroradiology Department (N.B., M.B.), Université de Lille (M.F., T.P., C.C., H.H.), Inserm U1171, Degenerative and Vascular Cognitive Disorders, CHU Lille, Department of Neurology, France; J. Philip Kistler Stroke Research Center (A.C., N.S.R.), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; and Neuroradiology Department (S.B.), Lorraine University, INSERM U1254 CHRU Nancy, France.ORCID 0000-0002-0733-0104
Pierre SenersFrom the Neuroradiology Department (G.B., W.B., J.B., L.L., D.T., C.R.-R., C.O., O.N.) and Neurology Department (G.T., P.S.), Paris Descartes University, INSERM U1266, DHU Neurovasculaire, Sainte-Anne Hospital, Paris; Neuroradiology Department (N.B., M.B.), Université de Lille (M.F., T.P., C.C., H.H.), Inserm U1171, Degenerative and Vascular Cognitive Disorders, CHU Lille, Department of Neurology, France; J. Philip Kistler Stroke Research Center (A.C., N.S.R.), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; and Neuroradiology Department (S.B.), Lorraine University, INSERM U1254 CHRU Nancy, France.ORCID 0000-0002-2134-0691
Thomas PersonnicFrom the Neuroradiology Department (G.B., W.B., J.B., L.L., D.T., C.R.-R., C.O., O.N.) and Neurology Department (G.T., P.S.), Paris Descartes University, INSERM U1266, DHU Neurovasculaire, Sainte-Anne Hospital, Paris; Neuroradiology Department (N.B., M.B.), Université de Lille (M.F., T.P., C.C., H.H.), Inserm U1171, Degenerative and Vascular Cognitive Disorders, CHU Lille, Department of Neurology, France; J. Philip Kistler Stroke Research Center (A.C., N.S.R.), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; and Neuroradiology Department (S.B.), Lorraine University, INSERM U1254 CHRU Nancy, France.
Laurence LegrandFrom the Neuroradiology Department (G.B., W.B., J.B., L.L., D.T., C.R.-R., C.O., O.N.) and Neurology Department (G.T., P.S.), Paris Descartes University, INSERM U1266, DHU Neurovasculaire, Sainte-Anne Hospital, Paris; Neuroradiology Department (N.B., M.B.), Université de Lille (M.F., T.P., C.C., H.H.), Inserm U1171, Degenerative and Vascular Cognitive Disorders, CHU Lille, Department of Neurology, France; J. Philip Kistler Stroke Research Center (A.C., N.S.R.), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; and Neuroradiology Department (S.B.), Lorraine University, INSERM U1254 CHRU Nancy, France.ORCID 0000-0003-3951-7405
Denis TrystramFrom the Neuroradiology Department (G.B., W.B., J.B., L.L., D.T., C.R.-R., C.O., O.N.) and Neurology Department (G.T., P.S.), Paris Descartes University, INSERM U1266, DHU Neurovasculaire, Sainte-Anne Hospital, Paris; Neuroradiology Department (N.B., M.B.), Université de Lille (M.F., T.P., C.C., H.H.), Inserm U1171, Degenerative and Vascular Cognitive Disorders, CHU Lille, Department of Neurology, France; J. Philip Kistler Stroke Research Center (A.C., N.S.R.), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; and Neuroradiology Department (S.B.), Lorraine University, INSERM U1254 CHRU Nancy, France.
Christine Rodriguez-RegentFrom the Neuroradiology Department (G.B., W.B., J.B., L.L., D.T., C.R.-R., C.O., O.N.) and Neurology Department (G.T., P.S.), Paris Descartes University, INSERM U1266, DHU Neurovasculaire, Sainte-Anne Hospital, Paris; Neuroradiology Department (N.B., M.B.), Université de Lille (M.F., T.P., C.C., H.H.), Inserm U1171, Degenerative and Vascular Cognitive Disorders, CHU Lille, Department of Neurology, France; J. Philip Kistler Stroke Research Center (A.C., N.S.R.), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; and Neuroradiology Department (S.B.), Lorraine University, INSERM U1254 CHRU Nancy, France.
Andreas CharidimouFrom the Neuroradiology Department (G.B., W.B., J.B., L.L., D.T., C.R.-R., C.O., O.N.) and Neurology Department (G.T., P.S.), Paris Descartes University, INSERM U1266, DHU Neurovasculaire, Sainte-Anne Hospital, Paris; Neuroradiology Department (N.B., M.B.), Université de Lille (M.F., T.P., C.C., H.H.), Inserm U1171, Degenerative and Vascular Cognitive Disorders, CHU Lille, Department of Neurology, France; J. Philip Kistler Stroke Research Center (A.C., N.S.R.), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; and Neuroradiology Department (S.B.), Lorraine University, INSERM U1254 CHRU Nancy, France.ORCID 0000-0001-5891-337X
Natalia S RostFrom the Neuroradiology Department (G.B., W.B., J.B., L.L., D.T., C.R.-R., C.O., O.N.) and Neurology Department (G.T., P.S.), Paris Descartes University, INSERM U1266, DHU Neurovasculaire, Sainte-Anne Hospital, Paris; Neuroradiology Department (N.B., M.B.), Université de Lille (M.F., T.P., C.C., H.H.), Inserm U1171, Degenerative and Vascular Cognitive Disorders, CHU Lille, Department of Neurology, France; J. Philip Kistler Stroke Research Center (A.C., N.S.R.), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; and Neuroradiology Department (S.B.), Lorraine University, INSERM U1254 CHRU Nancy, France.
Serge BracardFrom the Neuroradiology Department (G.B., W.B., J.B., L.L., D.T., C.R.-R., C.O., O.N.) and Neurology Department (G.T., P.S.), Paris Descartes University, INSERM U1266, DHU Neurovasculaire, Sainte-Anne Hospital, Paris; Neuroradiology Department (N.B., M.B.), Université de Lille (M.F., T.P., C.C., H.H.), Inserm U1171, Degenerative and Vascular Cognitive Disorders, CHU Lille, Department of Neurology, France; J. Philip Kistler Stroke Research Center (A.C., N.S.R.), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; and Neuroradiology Department (S.B.), Lorraine University, INSERM U1254 CHRU Nancy, France.
Charlotte CordonnierFrom the Neuroradiology Department (G.B., W.B., J.B., L.L., D.T., C.R.-R., C.O., O.N.) and Neurology Department (G.T., P.S.), Paris Descartes University, INSERM U1266, DHU Neurovasculaire, Sainte-Anne Hospital, Paris; Neuroradiology Department (N.B., M.B.), Université de Lille (M.F., T.P., C.C., H.H.), Inserm U1171, Degenerative and Vascular Cognitive Disorders, CHU Lille, Department of Neurology, France; J. Philip Kistler Stroke Research Center (A.C., N.S.R.), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; and Neuroradiology Department (S.B.), Lorraine University, INSERM U1254 CHRU Nancy, France.ORCID 0000-0002-5697-6892
Catherine OppenheimFrom the Neuroradiology Department (G.B., W.B., J.B., L.L., D.T., C.R.-R., C.O., O.N.) and Neurology Department (G.T., P.S.), Paris Descartes University, INSERM U1266, DHU Neurovasculaire, Sainte-Anne Hospital, Paris; Neuroradiology Department (N.B., M.B.), Université de Lille (M.F., T.P., C.C., H.H.), Inserm U1171, Degenerative and Vascular Cognitive Disorders, CHU Lille, Department of Neurology, France; J. Philip Kistler Stroke Research Center (A.C., N.S.R.), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; and Neuroradiology Department (S.B.), Lorraine University, INSERM U1254 CHRU Nancy, France.ORCID 0000-0003-3410-0862
Olivier NaggaraFrom the Neuroradiology Department (G.B., W.B., J.B., L.L., D.T., C.R.-R., C.O., O.N.) and Neurology Department (G.T., P.S.), Paris Descartes University, INSERM U1266, DHU Neurovasculaire, Sainte-Anne Hospital, Paris; Neuroradiology Department (N.B., M.B.), Université de Lille (M.F., T.P., C.C., H.H.), Inserm U1171, Degenerative and Vascular Cognitive Disorders, CHU Lille, Department of Neurology, France; J. Philip Kistler Stroke Research Center (A.C., N.S.R.), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; and Neuroradiology Department (S.B.), Lorraine University, INSERM U1254 CHRU Nancy, France.ORCID 0000-0002-9544-379X
Hilde HenonFrom the Neuroradiology Department (G.B., W.B., J.B., L.L., D.T., C.R.-R., C.O., O.N.) and Neurology Department (G.T., P.S.), Paris Descartes University, INSERM U1266, DHU Neurovasculaire, Sainte-Anne Hospital, Paris; Neuroradiology Department (N.B., M.B.), Université de Lille (M.F., T.P., C.C., H.H.), Inserm U1171, Degenerative and Vascular Cognitive Disorders, CHU Lille, Department of Neurology, France; J. Philip Kistler Stroke Research Center (A.C., N.S.R.), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; and Neuroradiology Department (S.B.), Lorraine University, INSERM U1254 CHRU Nancy, France.ORCID 0000-0001-6274-7562
Harvard University · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTo determine the influence of white matter hyperintensity (WMH) burden on functional outcome, rate of symptomatic intracerebral hemorrhage (sICH), and procedural success in patients with acute ischemic stroke (AIS) treated by mechanical thrombectomy (MT) with current stentriever/aspiration devices.
methodsPatients with AIS due to large vessel occlusion (LVO) from the Thrombectomie des Artères Cérébrales (THRACE) trial and prospective cohorts from 2 academic comprehensive stroke centers treated with MT were pooled and retrospectively analyzed. WMH volumes were obtained by semiautomated planimetric segmentation and tested in association with the rate of favorable outcome (90-day functional independence), substantial recanalization after MT, and sICH.
resultsA total of 496 participants were included between 2015 and 2018 (50% female, mean age 68.1 ± 15.0 years). Overall, 434 (88%) patients presented with detectable WMH (mean ± SD 4.93 ± 7.7). Patients demonstrated increasingly worse outcomes with increasing WMH volumes (odds ratio [aOR]1.05 per 1-cm
conclusionOur study provides evidence that in patients with AIS due to LVO and high burden of WMH as assessed by pretreatment MRI, the safety and efficacy profiles of MT are similar to those in patients with lower WMH burden and confirms that they are at higher risk of unfavorable outcome. Because more than a quarter of patients in the highest WMH quartile experienced favorable 3 months outcome, WMH burden may not be a good argument to deny MT. CLINICALTRIALSGOV IDENTIFIER: NCT01062698.
Indexed as
ThrombectomyAdultAgedAged, 80 and overBrain IschemiaCerebral HemorrhageFemaleHumansLeukoaraiosisMaleMiddle AgedProspective StudiesStrokeTreatment OutcomeWhite Matter
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Registered trials
NCT01062698ClinicalTrials.gov
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