Evidence map›Paper›PMID 31519746›Full record

ArticleG3 (Bethesda, Md.)2019

Chromosome Preference During Homologous Recombination Repair of DNA Double-Strand Breaks in

Joel Fernandez, Hanan Bloomer, Natalia Kellam, Jeannine R LaRocque

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Joel FernandezDepartment of Human Science, Georgetown University Medical Center, Washington DC 20057.
Hanan BloomerDepartment of Human Science, Georgetown University Medical Center, Washington DC 20057.
Natalia KellamDepartment of Human Science, Georgetown University Medical Center, Washington DC 20057.
Jeannine R LaRocqueDepartment of Human Science, Georgetown University Medical Center, Washington DC 20057 jan.larocque@georgetown.edu.ORCID 0000-0002-1523-9677
Georgetown University Medical Center · US

Funding

Mitotic DNA double-strand break repair in Drosophila melanogasterR15GM129628 · NIGMS · GEORGETOWN UNIVERSITY · PI LAROCQUE KAPPAS, JEANNINE · 2018 to 2018
$465k
NIGMS NIH HHS R15 GM129628
6 · The paper itself

Abstract

DNA double-strand breaks (DSBs) are especially toxic DNA lesions that, if left unrepaired, can lead to wide-ranging genomic instability. Of the pathways available to repair DSBs, the most accurate is homologous recombination (HR), where a homologous sequence is used as a donor template to restore genetic information at the break site. While much of the biochemical aspects of HR repair have been characterized, how the repair machinery locates and discriminates between potential homologous donor templates throughout the genome remains elusive. We use

Indexed as

Chromosomes, InsectDNA Breaks, Double-StrandedRecombinational DNA RepairAnimalsDrosophila melanogasterFemaleMaleDrosophila melanogasterDSB repairhomologous recombinationinterhomolog recombinationintrachromosomal recombination

Identifiers

PMID31519746
PMCPMC6829126
OpenAlexW2972967185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.